(01-04-2014, 19:11)peggy Wrote: Ella, I am taking Fenu already in my herbal mix. I will eventually use it until the end of this cycle and then make another mix.
Lotus, I know there are many opposing infos out there. But I found multiple articles that soy is bad and also hops, especially when you are estrogen dominant.
I am not sure what to think about PM.I found just a few human studies where the woman took just 50mg (or max. 100mg) of PM per day for six months, which is a very low dose.
Quote:In human interventions, doses up to 50mg have been used in interventions with no significant reported side-effects[34][29] and doses in the range of 25-100mg in open-label studies lasting up to 6 months have failed to show any relevant toxic effects.[26][27]
Currently no significant side-effects associated with supplemental Pueraria Mirifica at the standard supplemental dosages
And this:
Quote:In an Ames test, it appears that Pueraria (Mirifica and Lobata) do not possess any direct mutagenic effects regardless of whether or not they are bioactivated via S9 (to mimic cellular metabolism), but both were slightly antimutagenic when mutations were induced by either benzo(a)pyrene or 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide; lack of mutagenicitiy was seen with 300mg/kg oral ingestion in rats[62] although another study in male mice using higher doses of a water extract (600-800mg/kg, human equivalent dose of 96-128mg/kg) was able to induce a higher frequency of micronuclei formation, indicative of mutagenicity
Source: http://examine.com/supplements/Pueraria+mirifica/
I would love to take PM for all the other benefits (hair, skin etc) but I am not sure if it is really safe in higher dosages. What do you think, Lotus?
No I completely get it, high doses of anything is just not a good idea, long term affects isn't worth the risks. I'm guilty of doing the exact same thing, but I've learned that the hard way.
Concentrate on specific herbal actions, i.e. Tannins (astringent), prolactin source FG, fennel estrogenic source, ect.