Yes, Karen,
What caught my eye is this statement:
"Xanthohumol is a testosterone blocker (not a DHT blocker like most other antiandrogens)." I don't know what a "blocker" means here.
This is new to me too. I couldn't find a publication supporting this, but this one comes close. The abstract states that isoxanthohumol inhibits steroidogenesis in Leydig cells, which suggests that it inhibits synthesis of testosterone.
http://onlinelibrary.wiley.com/doi/10.1002/jat.1602/abstract;jsessionid=9275274585DAE180F505DEA6DDBC9AF0.d01t01?deniedAccessCustomisedMessage=&userIsAuthenticated=false
Hops extract lowers testosterone in ovariectomized obese rats:
http://en.cnki.com.cn/Article_en/CJFDTOT...402016.htm
Only this publication doesn't say how testosterone is decreased. It could be a stall.
There is an article stating that the conversion of isoxanthohumol to 8-prenylnaringenin is 90 %:
http://pubs.acs.org/doi/abs/10.1021/jf0509714
Hops definitely decreases my libido. I'm not alone: "Humulus lupulus extract exerted an anaphrodisiac effect only in naïve rats (not in sexually potent rats) by inhibiting their mounting and ejaculating behavior. The pure compound 8-PN failed to influence male sexual behavior of naïve rats."
http://www.sciencedirect.com/science/art...410900395X
Xanthohumol is definitely an anti-androgen. There is also a lot of literature saying it cures acne. So I always assumed it inhibits 5α-reductase type 1, because that's the type that's in skin. I just looked for literature confirming that xanthohumol inhibits 5α-reductase type 1, but couldn't find any.
Oats stimulate androgen activity only because they lower SHBG. So I use my oats together with the hops on purpose, because SHBG binds estrogens too. DHT binds stronger to SHBG than other steroids do. So in your program, the combination of testim with lower SHBG could cause explosive libido, yes.
What caught my eye is this statement:
"Xanthohumol is a testosterone blocker (not a DHT blocker like most other antiandrogens)." I don't know what a "blocker" means here.
This is new to me too. I couldn't find a publication supporting this, but this one comes close. The abstract states that isoxanthohumol inhibits steroidogenesis in Leydig cells, which suggests that it inhibits synthesis of testosterone.
http://onlinelibrary.wiley.com/doi/10.1002/jat.1602/abstract;jsessionid=9275274585DAE180F505DEA6DDBC9AF0.d01t01?deniedAccessCustomisedMessage=&userIsAuthenticated=false
Hops extract lowers testosterone in ovariectomized obese rats:
http://en.cnki.com.cn/Article_en/CJFDTOT...402016.htm
Only this publication doesn't say how testosterone is decreased. It could be a stall.
There is an article stating that the conversion of isoxanthohumol to 8-prenylnaringenin is 90 %:
http://pubs.acs.org/doi/abs/10.1021/jf0509714
Hops definitely decreases my libido. I'm not alone: "Humulus lupulus extract exerted an anaphrodisiac effect only in naïve rats (not in sexually potent rats) by inhibiting their mounting and ejaculating behavior. The pure compound 8-PN failed to influence male sexual behavior of naïve rats."
http://www.sciencedirect.com/science/art...410900395X
Xanthohumol is definitely an anti-androgen. There is also a lot of literature saying it cures acne. So I always assumed it inhibits 5α-reductase type 1, because that's the type that's in skin. I just looked for literature confirming that xanthohumol inhibits 5α-reductase type 1, but couldn't find any.
Oats stimulate androgen activity only because they lower SHBG. So I use my oats together with the hops on purpose, because SHBG binds estrogens too. DHT binds stronger to SHBG than other steroids do. So in your program, the combination of testim with lower SHBG could cause explosive libido, yes.