04-08-2011, 02:29 PM
PM starters write they feel "much better". I have been asking around about how exactly they feel. Pansy-Mae and IdreamofD and Susan gave me the level of detail I was looking for. It's all in four posts, and the link in the fourth post:
http://www.breastnexus.com/showthread.php?tid=8982&pid=33042#pid33042
They are enthousiastic about immediate benefits of higher estrogen (skin, hair, nails, lubrication), and about two benefits that are normally associated with higher progesterone: clearer thinking and improved mood.
PM webshops list improved mood among benefits. So I wondered what PM does about mood.
I found only one scientific study: 50 mg PM decreased mood instability in postmenopausal women after 1, 3, 6 months:
http://www.mat.or.th/journal/files/Vol90...0_6365.pdf
http://www.puresterol.com/articles/Phase%20I.pdf
http://www.puresterol.com/articles/2004%...uraria.pdf
The study had no placebo control group. So it's possible that what they saw is just the emotional benefit of doing something about the seven dwarfs of menopause
In searching scientific literature, it's not enough to google "pueraria mirifica". The botanical name of PM is "Pueraria candollei var. mirifica" or "Pueraria candollei var. mirifica A Shaw.". So google "Pueraria" without specifying "mirifica". Then weed out all the hits on kudzu.
Root cultures of P. candollei decrease malondialdehyde:
http://www.jstage.jst.go.jp/article/jhs/...2/_article
That can have an immediate benefit in joints:
http://en.wikipedia.org/wiki/Malondialdehyde
IdreamofD and Susan enjoyed improvements in joint pains.
In the above study on mood, there was still improvement between 3 and 6 months in on PM. This study suggests you may have to wait five months for the full benefits:
PM increases serum estradiol after five months on a low dose (50-100 mg):
http://www.ncbi.nlm.nih.gov/pubmed/14971532
http://www.breastnexus.com/showthread.php?tid=8982&pid=33042#pid33042
They are enthousiastic about immediate benefits of higher estrogen (skin, hair, nails, lubrication), and about two benefits that are normally associated with higher progesterone: clearer thinking and improved mood.
PM webshops list improved mood among benefits. So I wondered what PM does about mood.
I found only one scientific study: 50 mg PM decreased mood instability in postmenopausal women after 1, 3, 6 months:
http://www.mat.or.th/journal/files/Vol90...0_6365.pdf
http://www.puresterol.com/articles/Phase%20I.pdf
http://www.puresterol.com/articles/2004%...uraria.pdf
The study had no placebo control group. So it's possible that what they saw is just the emotional benefit of doing something about the seven dwarfs of menopause
In searching scientific literature, it's not enough to google "pueraria mirifica". The botanical name of PM is "Pueraria candollei var. mirifica" or "Pueraria candollei var. mirifica A Shaw.". So google "Pueraria" without specifying "mirifica". Then weed out all the hits on kudzu.
Root cultures of P. candollei decrease malondialdehyde:
http://www.jstage.jst.go.jp/article/jhs/...2/_article
That can have an immediate benefit in joints:
http://en.wikipedia.org/wiki/Malondialdehyde
IdreamofD and Susan enjoyed improvements in joint pains.
In the above study on mood, there was still improvement between 3 and 6 months in on PM. This study suggests you may have to wait five months for the full benefits:
PM increases serum estradiol after five months on a low dose (50-100 mg):
http://www.ncbi.nlm.nih.gov/pubmed/14971532