Pueraria Mirifica Just for Menopause Article Part 1
pueraria Mirifica Just For Menopause Article Part 2
reference 1+ for part 1 and 2+ for part 2
1+ Gordon: It occupies the estrogen receptors more safely. If the estrogen level is high, miroestrol will compete with receptors weakening the effect of the hormones. If the estrogen level is low, miroestrol will exert its estrogenic effect of potentiation.
1+ Passwater: So, the miroestrol in PM acts to balance or moderate estrogen effects, not by altering the amount of estrogen or other hormones in the body, but by miroestrol interacting with the estrogen receptors in tissues to normalize estrogenic effects. It seems to me that this could explain why studies show PM is so helpful for both perimenopausal and menopausal women.
1+ What effect does miroestrol have on natural hormones produced in the body? Gordon: None. The effect is only with the estrogen receptor. Passwater: So, the miroestrol in PM acts to balance or moderate estrogen effects, not by altering the amount of estrogen or other hormones in the body, but by miroestrol interacting with the estrogen receptors in tissues to normalize estrogenic effects. It seems to me that this could explain why studies show PM is so helpful for both perimenopausal and menopausal women.
2+ Gordon: Quite frankly, the only warning would be for women not to take PM before the age of 18. If a menstruating woman takes PM, the recommendation is not to take it during the week of her period. I have never heard of there being any consequence from taking it continuously, but Thai traditional medicine recommends younger women taking one week off. Also, I recommend very few supplements or medicines for pregnant women. There is no need for pregnant women to take PM as they are not menopausal, so I do not recommend PM for pregnant women.
2+ Gordon: 2 mg / kg body weight. For the first month that level can be doubled. So a 150-pound woman would require 136 mg of PM / day, but could take, without any problem, 272 mg (or 3 pills / day). Most women will see relief of symptoms in a week or less. The Phase I and the Phase II trials in Thailand were on Asian women, who are normally smaller than Western women, so the dosages they used were small, compared what Western women might need. A convenient and effective regimen for American women of menopausal age would be to take 80 mg of PM twice a day.
2+ The original breast enhancement study was done in Tokyo by Japanese Prof. Kuramoshi and Thai Assoc. Prof. Yuthana Smitasiri. They showed that 72% of women taking PM exhibited significant increases in breast size. Younger women had a markedly higher rate of success than older women, who lowered the overall success rate. Some years ago, a company in California launched ISIS, a system using real PM. They guaranteed success or your money back and had 96% satisfied customers, not asking for their money back.
2+ Gordon: A company I consult with, Longevity Plus, which produces supplements for professionals, has had very positive feedback regarding combining PM with vitamin B-12 and folic acid. I had recommended that they simply add this exciting PM herb into their proprietary B-12 formula, which alone had reportedly provided excellent support to many women, reducing fatigue, depression and irritability. Adding PM to that formula, we find, acts synergistically so that even the most difficult change of life issues that until now nothing has helped, are responding, often within two-to-four weeks. Therefore, I think PM should be combined with B-12 and folic acid.
