[Lotus]

Hi Nynuk,

I don't think deer antler or MK-66 is the answer for PCOS or for NBE. Look up the negative impact of adding IGF1 has here:
https://www.breastnexus.com/showthread.php?tid=22417&pid=208351&highlight=insulin+growth+factor#pid208351

At the bottom of the thread is a search function and type in Insulin Growth Factor and you'll find information on IGF-1. Also attached is how metformin helps improve IGF-1 by restoring insulin sensitivity, and thus this action heals IGF to naturally Produce IGF. Restoring IGF naturally doesn't have to come from just metformin, there's other ways. In the time (years) I've spent helping people (thousands) with their NBE goals I've not seen anyone gain breast growth by using IGF-1. The science I've seen points to using exogenous IGF-1 speeds up the aging process...this, we don't want. As I've outlined in earlier posts science has found new ways to increase longevity by utilizing the AMPK activators (like metformin).

Taking MK-677 carries risks. See there's a chance taking IGF-1 elevates breast hyperplasia and cancer. 

In luteal phase IGF-1 is naturally produced, people don't talk about this enough that IGF locally in the breast were doubled in the luteal, when estradiol and progesterone levels were elevated, compared with the follicular phase[/b].

So like I said, I'd rather see cis-females get IGF-1 naturally as opposed to supplementing with IGF-1. Just inhibit somatostatin and stimulate pituitary GH and you'll see IGF-1 come around.

Increase of Free Insulin-Like Growth Factor-1 in Normal Human Breast in vivo Late in the Menstrual Cycle

The results showed that the extracellular levels of free IGF-1 locally in the breast were doubled in the luteal phase, when estradiol and progesterone levels were elevated, compared with the follicular phase. In plasma, free IGF-1 levels also exhibited a cyclic variation but to a lesser extent. The increased local levels of the free form of IGF-1 may promote proliferation in the breast epithelium. This could be important in sex steroid dependent breast cancer development.
https://link.springer.com/article/10.102...4575103524

The role of the insulin-like growth factor-1 system in breast cancer

Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335664/



Growth Hormone and Insulin-Like Growth Factor-I in the Transition from Normal Mammary Development to Preneoplastic Mammary Lesions

For example, systemic administration of GH or IGF-I causes mammary hyperplasia, and overproduction of IGF-I in transgenic animals can cause the development of usual or atypical hyperplasias and sometimes carcinoma.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393153/#!po=63.1915[/color[/size]]
https://www.breastnexus.com/showthread.php?tid=22417&pid=208351&highlight=insulin+growth+factor#pid208351

The role of insulin-like growth factor-1 (IGF-1) and IGF binding protein-1 (IGFBP-1) in the pathogenesis of polycystic ovary syndrome 

It was concluded that women with PCOS have normal serum IGF-1 concentrations but IGFBP-1 levels, regulated by insulin, are low. Hyperinsulinaemia and raised LH are independently capable of stimulating ovarian androgen production. Growth factors may have an important role in the pathogenesis of PCOS. 

https://pubmed.ncbi.nlm.nih.gov/1283982/

Increased insulin-like growth factor-I levels in women with polycystic ovary syndrome, and beneficial effects of metformin therapy

By decreasing insulin and IGF-I levels, metformin therapy offers additional beneficial effects in resumption of regular menses. Thus, in PCOS patients with elevated levels of IGF-I, metformin may be considered as an appropriate agent to be used for the regulation of menstrual cycles.

https://pubmed.ncbi.nlm.nih.gov/15697073/


Metformin therapy increases insulin-like growth factor binding protein-1 in hyperinsulinemic women with polycystic ovary syndrome
Conclusions: The present study shows that metformin therapy not only restores normal levels of insulin and testosterone, but also decreases the pool of free-bioactive IGF-I by increasing the levels of circulating IGFBP-1. We provide further arguments in favor of metformin therapy in hyperinsulinemic women with PCOS.
https://pubmed.ncbi.nlm.nih.gov/15063962/