[surferjoe2007]

Appreciate the research surfer, i think this could be too risky as how invasive carcominas are:



Fibroblast Hepatocyte Growth Factor Promotes Invasion of Human Mammary Ductal Carcinoma in Situ 
Jedeszko C1, Victor BC, Podgorski I, Sloane BF.

Author information

Abstract
Stromal-derived hepatocyte growth factor (HGF) acting through its specific proto-oncogene receptor c-Met has been suggested to play a paracrine role in the regulation of tumor cell migration and invasion. The transition from preinvasive ductal carcinoma in situ (DCIS) to invasive breast carcinoma is marked by infiltration of stromal fibroblasts and the loss of basement membrane. We hypothesized that HGF produced by the infiltrating fibroblasts may alter proteolytic pathways in DCIS cells, and, to study this hypothesis, established three-dimensional reconstituted basement membrane overlay cocultures with two human DCIS cell lines, MCF10.DCIS and SUM102. Both cell lines formed large dysplastic structures in three-dimensional cultures that resembled DCIS in vivo and occasionally developed invasive outgrowths. In coculture with HGF-secreting mammary fibroblasts, the percentage of DCIS structures with invasive outgrowths was increased. Activation of c-Met with conditioned medium from HGF-secreting fibroblasts or with recombinant HGF increased the percentage of DCIS structures with invasive outgrowths, their degradation of collagen IV, and their secretion of urokinase-type plasminogen activator and its receptor. In agreement with the in vitro findings, coinjection with HGF-secreting fibroblasts increased invasiveness of MCF10.DCIS xenografts in severe combined immunodeficient mice. Our study shows that paracrine HGF/c-Met signaling between fibroblasts and preinvasive DCIS cells enhances the transition to invasive carcinomas and suggests that three-dimensional cocultures are appropriate models for testing therapeutics that target tumor microenvironment-enhanced invasiveness.


Btw, hepatocyte growth factor is not a hormone.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2789178/

Anything that causes cells to reproduce or breasts to grow increases risk for cancer.  Yes HGF is particularly dangerous in this respect.

Even with IGF the more I look into this the more it looks like it's somewhat dangerous, at least when injected.  Though in more proper amounts it seems quite beneficial in general, not just for the breasts.  Looking for more modest natural ways to increase IGF may be better.

Agreed. I do think however there's something else about nuetralizing antibodies (blocking HGF) that's worth looking into. If certain pathways are cutoff before cancerous proliferation, metastasis takes hold (from downstream pathways) it looks promising......(e.g. PI3K/Akt and MAPK axis).

I can't remember where I saw it, but,  macromastia was defined as 3% of the persons body weight, 

130lb person = 3.9lbs per breast. Anybody carrying around 5-6 pounds of boobage (per breast, or more) would know and could very well tell you the strain it puts on the person.......despite the desire for wanting GG's.

Looked at WADA's statement again and edited my post.  They lift their ban on deer antler because it has little IGF not because it has no IGF.  And they used to ban it in sports for the IGF.  So that seems to confirm there is a little IGF in velvet antler, which would be both much safer and legal to buy and use as a supplement.  Not as effective of course, but combines well with other parts of a program and unlike other substances leads to weight loss rather than weight gain.  Plus it has other benefits.  It's very nice in low amounts.

Besides very high IGF and HGF in macromastia cases, moderately higher IGF is found in women with large boobs too.  I also read about large chested women exercising their back, using good posture and so on to avoid any back pain.  Plus 32H's are only 2 pounds a boob, so even they aren't a major concern.  5-6 lbs each is 32O (or 36M, etc.):
http://kdwb.iheart.com/onair/the-dave-ry...-12418095/

I'm confused what you're getting at regarding HGF.  Is it a risk for cancer, or a way to avoid that risk?  Regardless IGF seems to be the main factor here (plus estrogen, progesterone and so on of course).  Even though it's not as great as IGF+HGF.  Plus with certain hormones the body can make HGF.