I've been taking a very low dose of Spironalactone as an AA prescribed my dermatologist, as i have high levels of delta-4-androstenedione (but slightly low levels of DHEA and normal testosterone).
I can say that it reduces my acne even thought i'm taking just 12mg/day.
I have started researching about spiro because in the label says that can cause breast growth. So i've researched on the internet and found women and men that have experienced breast enlargement with spiro.
What i've found first about Spiro:
"Spironolactone decreases 5-alpha reductase activity via increased clearance of testosterone secondary to augmented liver hydroxylase activity. In addition, it increases the level of steroid hormone binding globulin (SHBG), thus providing a sink that reduces circulating free testosterone as more is bound by the increased quantity of SHBG. The resultant effect of reducing free testosterone in circulation is an increased estrogenic state(...)Spironolactone also acts locally by competing with dihydrotestosterone (DHT) for cutaneous androgen receptors, thereby inhibiting testosterone and DHT binding."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315877/
---> "reducing free testosterone by increasing SHBG, and increased estrogenic state." ---> Well, for those who have aromatase based programs like me, reducing free testosterone and increasing SHBG it's not the way to go, i think. Increased SHBG will decrease free T and so there's less available for aromatase conversion into E, and also less free E because it will bind with SHBG, right? So why is it claimed "an increased estrogenic state"?
In this study claims the same thing. And show a decrease in Androstenedione levels and increased SHBG levels.
http://www.researchgate.net/publication/...4c6d25.pdf
BUT!!!!!
Now i've found some studies that even associate high levels of Androstenidione with Spironolactone treatment.
http://www.ncbi.nlm.nih.gov/pubmed/20926464
And there are reported cases in internet of patients that had their androstenedione levels increased with Spiro.
A 24 years old lady case:
http://www.endocrine-abstracts.org/ea/00...025p33.htm
A 48-year-old man case:
http://www.endocrine-abstracts.org/ea/00...031p74.htm
"It is important to recognise spironolactone assay interference; the increased levels of androstenedione as well as cortisol would raise the possibility of adrenal malignancy"
I can say that it reduces my acne even thought i'm taking just 12mg/day.
I have started researching about spiro because in the label says that can cause breast growth. So i've researched on the internet and found women and men that have experienced breast enlargement with spiro.
What i've found first about Spiro:
"Spironolactone decreases 5-alpha reductase activity via increased clearance of testosterone secondary to augmented liver hydroxylase activity. In addition, it increases the level of steroid hormone binding globulin (SHBG), thus providing a sink that reduces circulating free testosterone as more is bound by the increased quantity of SHBG. The resultant effect of reducing free testosterone in circulation is an increased estrogenic state(...)Spironolactone also acts locally by competing with dihydrotestosterone (DHT) for cutaneous androgen receptors, thereby inhibiting testosterone and DHT binding."
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315877/
---> "reducing free testosterone by increasing SHBG, and increased estrogenic state." ---> Well, for those who have aromatase based programs like me, reducing free testosterone and increasing SHBG it's not the way to go, i think. Increased SHBG will decrease free T and so there's less available for aromatase conversion into E, and also less free E because it will bind with SHBG, right? So why is it claimed "an increased estrogenic state"?
In this study claims the same thing. And show a decrease in Androstenedione levels and increased SHBG levels.
http://www.researchgate.net/publication/...4c6d25.pdf
BUT!!!!!
Now i've found some studies that even associate high levels of Androstenidione with Spironolactone treatment.
http://www.ncbi.nlm.nih.gov/pubmed/20926464
And there are reported cases in internet of patients that had their androstenedione levels increased with Spiro.
A 24 years old lady case:
http://www.endocrine-abstracts.org/ea/00...025p33.htm
A 48-year-old man case:
http://www.endocrine-abstracts.org/ea/00...031p74.htm
"It is important to recognise spironolactone assay interference; the increased levels of androstenedione as well as cortisol would raise the possibility of adrenal malignancy"
