29-06-2016, 04:01 AM
Huggs,
I think we should give cimetidine/Tagamet a serious look at reducing CFS (chronic fatigue syndrome).
DRUG CLASS AND MECHANISM: Cimetidine is a drug that blocks the production of acid by acid-producing cells in the stomach and can be administered orally, IM or IV. It belongs to a class of drugs called H2 (histamine-2) blockers that also includes ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid). Histamine is a naturally-occurring chemical that stimulates cells in the stomach (parietal cells) to produce acid. H2-blockers inhibit the action of histamine on the cells, thus reducing the production of acid by the stomach. Since excessive stomach acid can damage the esophagus, stomach, and duodenum by reflux and lead to inflammation and ulceration, reducing stomach acid prevents and allows acid-induced inflammation and ulcers to heal. Cimetidine was approved by the FDA in 1977.
http://www.medicinenet.com/script/main/m...clekey=839
Now, if we follow this trail I believe it addresses brain/gut acid and a reduction of pain receptors associated with CFS, fibromyalgia too, or tied to many of the " immune and stress-responsive systems-----aka-brain-gut axis ".
One other bonus is how cimetidine can inhibit the CYP17 androgen pathway. I didn't think cimetidine had what it took for denying androgen production, but.........inhibiting CYP17 is at the top of the food chain (albeit the steroidgenous chain of enzymes).
Careful on the interactions though, cimetidine combined with birth control can send E2 into the stratosphere.
I think we should give cimetidine/Tagamet a serious look at reducing CFS (chronic fatigue syndrome).
DRUG CLASS AND MECHANISM: Cimetidine is a drug that blocks the production of acid by acid-producing cells in the stomach and can be administered orally, IM or IV. It belongs to a class of drugs called H2 (histamine-2) blockers that also includes ranitidine (Zantac), nizatidine (Axid), and famotidine (Pepcid). Histamine is a naturally-occurring chemical that stimulates cells in the stomach (parietal cells) to produce acid. H2-blockers inhibit the action of histamine on the cells, thus reducing the production of acid by the stomach. Since excessive stomach acid can damage the esophagus, stomach, and duodenum by reflux and lead to inflammation and ulceration, reducing stomach acid prevents and allows acid-induced inflammation and ulcers to heal. Cimetidine was approved by the FDA in 1977.
http://www.medicinenet.com/script/main/m...clekey=839
Now, if we follow this trail I believe it addresses brain/gut acid and a reduction of pain receptors associated with CFS, fibromyalgia too, or tied to many of the " immune and stress-responsive systems-----aka-brain-gut axis ".
One other bonus is how cimetidine can inhibit the CYP17 androgen pathway. I didn't think cimetidine had what it took for denying androgen production, but.........inhibiting CYP17 is at the top of the food chain (albeit the steroidgenous chain of enzymes).
Careful on the interactions though, cimetidine combined with birth control can send E2 into the stratosphere.