07-04-2015, 11:58 PM
Hi Clelia, I'm back on FAS lol. 
Lipid Catabolism: Fatty Acids & Triacylglycerols
Control of fatty acid oxidation is exerted mainly at the step of fatty acid entry into mitochondria.
Free fatty acids, which in solution have detergent properties, are transported in the blood bound to albumin, a serum protein produced by the liver.
Several proteins have been identified that facilitate transport of long chain fatty acids into cells, including the plasma membrane protein CD36.
Fatty acids are degraded in the mitochondrial matrix via the b-Oxidation Pathway. For most steps of the pathway there are multiple enzymes specific for particular fatty acid chain lengths. Many of the constituent enzymes are soluble proteins located in the mitochondrial matrix. But enzymes specific for very long chain fatty acids are associated with the inner mitochondrial membrane, facing the matrix.
Fatty acyl-CoA formed outside the mitochondria can pass through the outer mitochondrial membrane, which contains large VDAC channels, but cannot penetrate the mitochondrial inner membrane.
http://www.rpi.edu/dept/bcbp/molbiochem/...m#activate
Index of Key-words
http://www.rpi.edu/dept/bcbp/molbiochem/...xlist.html
________________________________
Pyruvate Dehydrogenase & Krebs Cycle
Pathway localization:
Glycolysis enzymes are located in the cytosol of cells. Pyruvate enters the mitochondrion to be metabolized further.
Mitochondrial compartments:
The mitochondrial matrix contains Pyruvate Dehydrogenase and enzymes of Krebs Cycle, plus other pathways such as fatty acid oxidation.
The inner membrane is the major permeability barrier of the mitochondrion. It contains various transport catalysts, including a carrier protein that allows pyruvate to enter the matrix. It is highly convoluted, with infoldings called cristae. Embedded in the inner membrane are constituents of the respiratory chain and ATP Synthase.
http://www.rpi.edu/dept/bcbp/molbiochem/.../krebs.htm
Lipid Catabolism: Fatty Acids & Triacylglycerols
Control of fatty acid oxidation is exerted mainly at the step of fatty acid entry into mitochondria.
Free fatty acids, which in solution have detergent properties, are transported in the blood bound to albumin, a serum protein produced by the liver.
Several proteins have been identified that facilitate transport of long chain fatty acids into cells, including the plasma membrane protein CD36.
Fatty acids are degraded in the mitochondrial matrix via the b-Oxidation Pathway. For most steps of the pathway there are multiple enzymes specific for particular fatty acid chain lengths. Many of the constituent enzymes are soluble proteins located in the mitochondrial matrix. But enzymes specific for very long chain fatty acids are associated with the inner mitochondrial membrane, facing the matrix.
Fatty acyl-CoA formed outside the mitochondria can pass through the outer mitochondrial membrane, which contains large VDAC channels, but cannot penetrate the mitochondrial inner membrane.
http://www.rpi.edu/dept/bcbp/molbiochem/...m#activate
Index of Key-words
http://www.rpi.edu/dept/bcbp/molbiochem/...xlist.html
________________________________
Pyruvate Dehydrogenase & Krebs Cycle
Pathway localization:
Glycolysis enzymes are located in the cytosol of cells. Pyruvate enters the mitochondrion to be metabolized further.
Mitochondrial compartments:
The mitochondrial matrix contains Pyruvate Dehydrogenase and enzymes of Krebs Cycle, plus other pathways such as fatty acid oxidation.
The inner membrane is the major permeability barrier of the mitochondrion. It contains various transport catalysts, including a carrier protein that allows pyruvate to enter the matrix. It is highly convoluted, with infoldings called cristae. Embedded in the inner membrane are constituents of the respiratory chain and ATP Synthase.
http://www.rpi.edu/dept/bcbp/molbiochem/.../krebs.htm