08-12-2022, 09:02 PM
Hi Sweets,
Anything that passes through the liver is subjected to the first pass metabolism versus more potent extracts. I added a couple threads I made in the past for reference, maybe it'll help someone.
FAQ-Absorption/When to take supplements
https://www.breastnexum.com/showthread.php?tid=21689
FAQ-Liquid Herbal Extracts (alcohol content)
https://www.breastnexus.com/showthread.php?tid=21260
I'd stick with the 600mg as used in the original research paper. Especially seeing how PCOS and Subclinical Hypothyroidism are at increased risk of hyperglycemia (citation below) We know that when used in high amounts Fenugreek lowers blood sugars (known as hyperglycemia).
More than half of subjects with PCOS are associated with IR, hyperglycemia, weight gain, and finally metabolic syndrome (MBS)
A similar picture is also shared by hypothyroidism due to associated hyperglycemia, raised levels of sex hormone binding globulin (SHBG), and dyslipidemia [2, 4, 5]
Subclinical Hypothyroidism in PCOS: Impact on Presentation, Insulin Resistance, and Cardiovascular Risk
https://www.hindawi.com/journals/bmri/2016/2067087/
Anything that passes through the liver is subjected to the first pass metabolism versus more potent extracts. I added a couple threads I made in the past for reference, maybe it'll help someone.
FAQ-Absorption/When to take supplements
https://www.breastnexum.com/showthread.php?tid=21689
FAQ-Liquid Herbal Extracts (alcohol content)
https://www.breastnexus.com/showthread.php?tid=21260
I'd stick with the 600mg as used in the original research paper. Especially seeing how PCOS and Subclinical Hypothyroidism are at increased risk of hyperglycemia (citation below) We know that when used in high amounts Fenugreek lowers blood sugars (known as hyperglycemia).
More than half of subjects with PCOS are associated with IR, hyperglycemia, weight gain, and finally metabolic syndrome (MBS)
A similar picture is also shared by hypothyroidism due to associated hyperglycemia, raised levels of sex hormone binding globulin (SHBG), and dyslipidemia [2, 4, 5]
Subclinical Hypothyroidism in PCOS: Impact on Presentation, Insulin Resistance, and Cardiovascular Risk
https://www.hindawi.com/journals/bmri/2016/2067087/