14-02-2015, 05:18 PM
Please read:
(20-08-2014, 12:26 AM)Lotus Wrote:(19-08-2014, 10:08 PM)Lotus Wrote: Everyone should read this about Genistein, (one of phytoestrogens in PM and other products).
Also note that increased consumption of soy products reduces plasma concentrations of estradiol.
Genistein: does it prevent or promote breast cancer?
http://www.ncbi.nlm.nih.gov/pmc/articles...9-0057.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles...85/?page=1
From pg. 702 Possible Anti-Estrogenic Effects of Genistein
Genistein has significant estrogenic properties in both in vitro and in vivomodels (Table1). Genistein binds to the estrogen receptor(ER), although its binding affinity is several-fold weaker than that of estradiol(30). Genistein can also activate a number of estrogen-responsive genes in vitro, including pS2 and c-fos (18,31). Furthermore, when administered at low doses, genistein stimulates the growth of ER-positive(ER+) breast cancer cells (18-20). Findings in other tissue systems support the estrogenicity of genistein. For example, genistein is uterotrophic in a variety of species, resulting in impaired reproductive activity and increases inuterine wet weights.
Phytoestrogens and diseases of the prostate gland.
In particular, soya contains the isoflavone genistein, a compound with many properties which could influence both endocrine and growth factor signalling pathways.
http://www.ncbi.nlm.nih.gov/pubmed/?term...98)80008-6