21-06-2014, 02:44 AM
unfortunately, this study is about cancer cells. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601661/ It says agigenin, naringenin, and Kaempferol don't downregulate PRB but progesterone does.
See section 'Kaempferol, apigenin, and naringenin did not downregulate PRA or PRB expression in T47D breast epithelial cells'
"Cells exposed to 1 μM P4 for 1.5 h (Figure 6A) or 16 h (Figure 6B) [progesterone] exhibited downregulation of PRB and more noticeably PRA, which was not observed with 100 μM [phytoprogestins] kaempferol, apigenin, and naringenin treatments."
Especially see 'Discussion' section
See section 'Kaempferol, apigenin, and naringenin did not downregulate PRA or PRB expression in T47D breast epithelial cells'
"Cells exposed to 1 μM P4 for 1.5 h (Figure 6A) or 16 h (Figure 6B) [progesterone] exhibited downregulation of PRB and more noticeably PRA, which was not observed with 100 μM [phytoprogestins] kaempferol, apigenin, and naringenin treatments."
Especially see 'Discussion' section