[Dynseli]

your link said isoflavonoids have a preference to ER-beta (ER-β).

I believe it was genistein that is the most potent in most isoflavonoids, and it has a preference and activation (also called transcription) for ER-beta. isoflavonoids generally come from the Fabaceae (includes beans, legumes etc) family. Some in that family like fenugreek and pueraria m have a potent phytohormone that isn't an isoflavonoid.

I'm having trouble finding the source that said red clover's effects, but it was a pubmed or pmc source that had clover and hops in its title. It also doesn't make sense for most in the fabaecae family to have er-alpha activation (pro) effects, since most people eat beans as a staple.

When looking at receptor activation, the paper I saw says a lot about receptor binding that seems to go all over the place, then it concludes which one caused the most activation (transcription). Also look at which types of cells it activates MCF-7 is a testtube cancer cell.

generally lactogogues have an affinity for ER-alpha (ER-α)

I edited my above post, because I miswrote the wrong word.