10-03-2010, 11:10 AM
progesterone findings-- important for girls taking synthetic hormones in their BCP!
August 20 2006 at 12:29 PM drummachic275 (no login)
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Extract taken from Dr Dalton’s book “Once a Month”
PROGESTOGENS
Because progesterone cannot be given orally, biochemists tried to make a synthetic preparation that could swallowed. They tried small alterations in the chemical formula, hoping to find a compound with slightly different properties; after all, progesterone, estrogen, testosterone, and cortisone all have very similar formulas, although they have quite different properties. Eventually they developed the "progestogens," or "progestins," which are the basis of all contraceptive pills and gave rise to a multibillion-dollar industry. When the progestogens were first developed, they were believed to be true progesterone substitutes. But, in fact, they had some properties of estrogen, some of progesterone, and some of testosterone. For example, if progestogens have been given during a pregnancy and the child is a girl, she is likely to show masculinizing effects in her genitals and be a tomboy, with marked aggression. This is quite different from the effect of natural progesterone, which is produced in such large quantities during pregnancy. Indeed, surveys have suggested that if progesterone is given to a mother before the sixteenth week of pregnancy for eight weeks or longer, the child of that pregnancy has a tendency toward enhanced intelligence, higher grades, and a better chance of reaching university level than control children whose mothers are not given progesterone (see page 256).
There are many differences between progesterone and the various progestogens, but unfortunately, there are still some doctors who do not realize this. Progesterone lowers the blood pressure, while progestogens raise it; and while progesterone raises the SHBG level, progestogens lower it (see pages 22, 24). Progestogens are not accepted by progesterone receptors. Progesterone can relieve water and sodium retention, whereas some progestogens used in the Pill, such as norethisterone, cause retention of water and sodium. Progesterone is converted by the adrenals into all the various corticosteroids, which is not possible with progestogens. One function of progesterone is to maintain a pregnancy, but the progestogens cannot be used for this purpose. Some progestogens have an estrogenic effect as well, which is useful in the contraceptive field. The disposal of progestogens from the body differs from that of natural progesterone, which is excreted in the urine and feces as pregnanediol.
Progestogens also lower the blood level of progesterone (see Figure 19), and this explains why women with PMS so often have difficulty in tolerating the Pill (see pages 152-154), whether the estrogen-progestogen pill or the progestogen-only pill, and also other estrogen/progestogen
preparations for menopause (see page 154).
Some doctors believe that by eliminating ovulation and menstruation with the use of strong progestogens such as danazol, it is possible to eliminate PMS. Unfortunately, this does not happen-it merely prolongs the premenstrual symptoms throughout the cycle. On the other hand, danazol is often the drug of choice in the treatment of endometriosis.
..............................................................................
PMS Is a Hormonal Disease
• Symptoms are related to the timing of progesterone levels in the premenstruum.
• Symptoms ease during pregnancy when high levels of placental progesterone are present.
• Symptoms recur immediately after pregnancy when there is a sudden loss of placental
progesterone
• Progesterone levels rise a thousand times in the premenstruum.
• Progesterone receptors are needed for the functioning of progesterone.
• The functioning of progesterone is not indicated by measurements of the blood levels of
progesterone, which are normal in women with PMS.
• Progesterone receptors are present at the sites of PMS symptoms.
• Progesterone receptors do not transport progestogens to the nuclei.
• Progesterone receptors do not function in the presence of adrenaline or low glucose level. High
doses of progesterone are needed to stimulate progesterone receptors.
Just thought I'd throw this in!
August 20 2006 at 12:29 PM drummachic275 (no login)
--------------------------------------------------------------------------------
Extract taken from Dr Dalton’s book “Once a Month”
PROGESTOGENS
Because progesterone cannot be given orally, biochemists tried to make a synthetic preparation that could swallowed. They tried small alterations in the chemical formula, hoping to find a compound with slightly different properties; after all, progesterone, estrogen, testosterone, and cortisone all have very similar formulas, although they have quite different properties. Eventually they developed the "progestogens," or "progestins," which are the basis of all contraceptive pills and gave rise to a multibillion-dollar industry. When the progestogens were first developed, they were believed to be true progesterone substitutes. But, in fact, they had some properties of estrogen, some of progesterone, and some of testosterone. For example, if progestogens have been given during a pregnancy and the child is a girl, she is likely to show masculinizing effects in her genitals and be a tomboy, with marked aggression. This is quite different from the effect of natural progesterone, which is produced in such large quantities during pregnancy. Indeed, surveys have suggested that if progesterone is given to a mother before the sixteenth week of pregnancy for eight weeks or longer, the child of that pregnancy has a tendency toward enhanced intelligence, higher grades, and a better chance of reaching university level than control children whose mothers are not given progesterone (see page 256).
There are many differences between progesterone and the various progestogens, but unfortunately, there are still some doctors who do not realize this. Progesterone lowers the blood pressure, while progestogens raise it; and while progesterone raises the SHBG level, progestogens lower it (see pages 22, 24). Progestogens are not accepted by progesterone receptors. Progesterone can relieve water and sodium retention, whereas some progestogens used in the Pill, such as norethisterone, cause retention of water and sodium. Progesterone is converted by the adrenals into all the various corticosteroids, which is not possible with progestogens. One function of progesterone is to maintain a pregnancy, but the progestogens cannot be used for this purpose. Some progestogens have an estrogenic effect as well, which is useful in the contraceptive field. The disposal of progestogens from the body differs from that of natural progesterone, which is excreted in the urine and feces as pregnanediol.
Progestogens also lower the blood level of progesterone (see Figure 19), and this explains why women with PMS so often have difficulty in tolerating the Pill (see pages 152-154), whether the estrogen-progestogen pill or the progestogen-only pill, and also other estrogen/progestogen
preparations for menopause (see page 154).
Some doctors believe that by eliminating ovulation and menstruation with the use of strong progestogens such as danazol, it is possible to eliminate PMS. Unfortunately, this does not happen-it merely prolongs the premenstrual symptoms throughout the cycle. On the other hand, danazol is often the drug of choice in the treatment of endometriosis.
..............................................................................
PMS Is a Hormonal Disease
• Symptoms are related to the timing of progesterone levels in the premenstruum.
• Symptoms ease during pregnancy when high levels of placental progesterone are present.
• Symptoms recur immediately after pregnancy when there is a sudden loss of placental
progesterone
• Progesterone levels rise a thousand times in the premenstruum.
• Progesterone receptors are needed for the functioning of progesterone.
• The functioning of progesterone is not indicated by measurements of the blood levels of
progesterone, which are normal in women with PMS.
• Progesterone receptors are present at the sites of PMS symptoms.
• Progesterone receptors do not transport progestogens to the nuclei.
• Progesterone receptors do not function in the presence of adrenaline or low glucose level. High
doses of progesterone are needed to stimulate progesterone receptors.
Just thought I'd throw this in!