11-03-2010, 11:00
Skin absorption
August 3 2007 at 7:46 AM Moon (Login -Moon-)
SENIOR MEMBER
--------------------------------------------------------------------------------
There has been much discussion about transdermal appliaction of all NBE related substances, so I will make the summary of the theory here:
1. Only small and lipid soluable molecules can penetrate the skin. This includes some vitamins and some hormones, but not proteins (including collagen).
2. Phytoestrogens from creams, tinctures and extracts used in NBE are absorbed, but they bypass the liver and don't undergo processing there. This may make the compound more effective, because it is retaind in the body for a loner time (liver degrades and eliminates compounds from the body). But the liver also activates some compounds that enter the body in an inactive form. In this case transdermal application is less effective.
3. Applying large molecules (such as proteins) only resuls in creating a water impermeable layer on the skin causing it to retain moisture.
Articles for further reading:
http://www.abc.net.au/cgi-bin/common/printfriendly.pl?/science/features/wrinkle/default.htm
http://molinterv.aspetjournals.org/cgi/content/full/4/6/308
Author Reply
Moon
(Login -Moon-)
SENIOR MEMBER Re: Skin absorption June 4 2008, 9:29 AM
In the frame of the heated cocoa butter debate, there has been a lot of dispute of whether or not FATS penetrate the skin. Here are my findings:
The previous sources inform me that molecules with the molecular weight up to about 500 Da (daltons) can pass the skin. I calculated the molecular weight of this fat molecule:
http://biology.clc.uc.edu/graphics/bio104/fat.jpg
It's 552 Da. This is a very small fat molecule - the fatty acid chains are only 10 carbon atoms long. Usually they are 12 to 16, often 18 and 22. So it seems that fats do not penetrate the skin.
However, fatty acids do, and this is used in cosmetic and other industry for delivery of substances across the skin in small ''bubbles'' made from fatty acids.
Fatty acid:
http://biology.clc.uc.edu/graphics/bio104/fatty%20acid.jpg
August 3 2007 at 7:46 AM Moon (Login -Moon-)
SENIOR MEMBER
--------------------------------------------------------------------------------
There has been much discussion about transdermal appliaction of all NBE related substances, so I will make the summary of the theory here:
1. Only small and lipid soluable molecules can penetrate the skin. This includes some vitamins and some hormones, but not proteins (including collagen).
2. Phytoestrogens from creams, tinctures and extracts used in NBE are absorbed, but they bypass the liver and don't undergo processing there. This may make the compound more effective, because it is retaind in the body for a loner time (liver degrades and eliminates compounds from the body). But the liver also activates some compounds that enter the body in an inactive form. In this case transdermal application is less effective.
3. Applying large molecules (such as proteins) only resuls in creating a water impermeable layer on the skin causing it to retain moisture.
Articles for further reading:
http://www.abc.net.au/cgi-bin/common/printfriendly.pl?/science/features/wrinkle/default.htm
http://molinterv.aspetjournals.org/cgi/content/full/4/6/308
Author Reply
Moon
(Login -Moon-)
SENIOR MEMBER Re: Skin absorption June 4 2008, 9:29 AM
In the frame of the heated cocoa butter debate, there has been a lot of dispute of whether or not FATS penetrate the skin. Here are my findings:
The previous sources inform me that molecules with the molecular weight up to about 500 Da (daltons) can pass the skin. I calculated the molecular weight of this fat molecule:
http://biology.clc.uc.edu/graphics/bio104/fat.jpg
It's 552 Da. This is a very small fat molecule - the fatty acid chains are only 10 carbon atoms long. Usually they are 12 to 16, often 18 and 22. So it seems that fats do not penetrate the skin.
However, fatty acids do, and this is used in cosmetic and other industry for delivery of substances across the skin in small ''bubbles'' made from fatty acids.
Fatty acid:
http://biology.clc.uc.edu/graphics/bio104/fatty%20acid.jpg