30-09-2012, 03:19
That's also a very good possibility... Increased SHBG, whatever it's cause, could explain all sorts of problems.
And various other ways in which our hormones mess about with each other in ever widening circles of loopbacking.
IF she in fact IS low on hormones, then there's definitely some SHBG or some loopback signals getting messed with.
Be careful with the definition of "true" estrogen insensitivity. It's just like with androgen insensitivity, there's full and there's various levels of partial effecting various ranges and classes of receptors. Yes. "True" estrogen insensitivity has had very very very precious few reported actual cases... This would be the full sort. And would have dire and immediately recognizable consequences.
But partial? In men a partial that only effects the beta class of estrogen receptors would go completely unnoticed. The beta class only exists in feminine tissues. In females? It could still take an awful long time before being noticed especially if it also only effected a very small range... say... in the breast tissue only.
Breast-tissue centric, Beta-class only, partial estrogen insensitivity would lead to a severely decreased growth rate in the breasts and a complete lack of receptivity towards PM and many other phytoestrogens which seem to bind more readily to the beta receptors than the alpha receptors.
So... what all that scientific mumbo-jumbo boils down to? It's still possible, that a very limited form of partial estrogen insensitivity, COULD be effecting lled. Nothing is certain, and she'd have to have the theory checked by an endo, but it is POSSIBLE. Even if she did have it checked, there's nothing that can be done for it.
What she's essentially doing with the noogling is increasing her number of receptors, and if the beta receptors are non-receptive, then she needs a LOT more receptors for the alpha's to pick up the slack.
It perhaps would have been even better if she had been noogling while in early puberty with the massive flood of hormones during that time.
And various other ways in which our hormones mess about with each other in ever widening circles of loopbacking.
IF she in fact IS low on hormones, then there's definitely some SHBG or some loopback signals getting messed with.
Be careful with the definition of "true" estrogen insensitivity. It's just like with androgen insensitivity, there's full and there's various levels of partial effecting various ranges and classes of receptors. Yes. "True" estrogen insensitivity has had very very very precious few reported actual cases... This would be the full sort. And would have dire and immediately recognizable consequences.
But partial? In men a partial that only effects the beta class of estrogen receptors would go completely unnoticed. The beta class only exists in feminine tissues. In females? It could still take an awful long time before being noticed especially if it also only effected a very small range... say... in the breast tissue only.
Breast-tissue centric, Beta-class only, partial estrogen insensitivity would lead to a severely decreased growth rate in the breasts and a complete lack of receptivity towards PM and many other phytoestrogens which seem to bind more readily to the beta receptors than the alpha receptors.
So... what all that scientific mumbo-jumbo boils down to? It's still possible, that a very limited form of partial estrogen insensitivity, COULD be effecting lled. Nothing is certain, and she'd have to have the theory checked by an endo, but it is POSSIBLE. Even if she did have it checked, there's nothing that can be done for it.
What she's essentially doing with the noogling is increasing her number of receptors, and if the beta receptors are non-receptive, then she needs a LOT more receptors for the alpha's to pick up the slack.
It perhaps would have been even better if she had been noogling while in early puberty with the massive flood of hormones during that time.