30-05-2023, 06:11
(24-05-2023, 11:57)Grayson123 Wrote: Domperidone doesn't cause cardiac arrhythmia except in a study that was done when people were taking huge doses intravenously. The standard oral dose is very low in comparison.
I'm not sure it's so clear. There are plenty of studies with oral domperidone, some have found domperidone prolongs the QTc, so one also has to consider if they are on other medications that do the same thing, as well as if there is a congenital condition.
This study found an increased risk of sudden cardiac death: https://pubmed.ncbi.nlm.nih.gov/20925438/
This study found an increased risk of severe arrhythmias, but they thought it was due to confounding (however they don't give an explanation except that it was a small increased effect, but if that was the case it would look the same):
https://www.nature.com/articles/s41598-020-69053-4
One of the reasons why there isn't a lot of data is because it is prohibited in many places.
If taking it, it would be safer to monitor the QTc and make sure nothing happens.