[WEENE]

@ bustprincess, Depression is linked to systemic inflammation. I wouldn't get hung up on whether depression is called a disease, illness or disorder...most diseases start as systemic inflammation. 


Implications of Systemic Inflammation and Periodontitis for Major Depression

Increasing evidence suggests that infection and persistent low-grade inflammation in peripheral tissues are important pathogenic factors that explain a possible pathophysiological mechanism of major depression. Systemic inflammation could induce depressive moods and behavioral changes by provoking neuroinflammation.
https://www.frontiersin.org/articles/10.3389/fnins.2018.00483/full

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Causes of Depression
By Debra Fulghum Bruce, PhD 
Medically Reviewed by Smitha Bhandari, MD on March 08, 2021

Have you ever wondered what causes clinical depression? Perhaps you have been diagnosed with major depression, and that's made you question why some people get depressed but others don't. 

Depression is a complex disease. No one knows exactly what causes it, but it can happen for a variety of reasons. Some people have depression during a serious medical illness. Others may have depression with life changes such as a move or the death of a loved one. Still others have a family history of depression. Those who do may have depression and feel overwhelmed with sadness and loneliness for no known reason 

https://www.webmd.com/depression/guide/causes-depression

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Depression: the radical theory linking it to inflammation

Alison Abbott considers a persuasive case for the link between body and mind.

A range of research showed that proteins in the body could reach the brain. These included inflammatory proteins called cytokines that were churned out in times of infection by immune cells called macrophages. Bullmore pulls together evidence that this echo of inflammation in the brain can be linked to depression.
https://www.nature.com/articles/d41586-018-05261-3

Five Things to Know About Inflammation and Depression:
Another pivotal point is that increased inflammation not only occurs in depression but also in multiple other psychiatric diseases including ...
https://www.psychiatrictimes.com/view/five-things-know-about-inflammation-and-depression

Nice articles Lotus!!
I've read about cytokines before, even though excersice is another alternative treatment for depression in excess leads to increased cytokines levels which can worsen depression levels but I didn't knew it was because it could cause inflamation on the brain. I thought they were anti-inflamatory...
Is always great to learn new things, thanks!!