10-07-2020, 08:30
I don't think having PCOS means it has to be a lifelong battle. It's reported that 88% of women with PCOS are related to insulin resistance (IR), and of the 12% it'll be from adrenal issues.
And this is where metformin comes in. Metformin lowers the insulin response (or insulin resistance), meaning lowering blood glucose.
But let's back things up for a minute and start with stomach acid. See if the PCOS dysfunction can be controlled it needs to start with inhibiting stomach gastrin.
Metformin has side effects of nausea, diarrhoea, flatulence, bloating, anorexia, metallic taste and abdominal pain.
Metformin stimulates AMP-activated protein kinase (AMPK) and is also referred to as the master regulator of energy homeostasis. There is however a conflict with metformin as it inhibits aromatase (via AMPK production), meaning it inhibits breast growth.
Role of metformin in the management of polycystic ovary syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475283/#!po=0.602410
I refer to metformin here because of its action, lowering insulin.
Reducing inflammation can start in the mitochondria, which is its place of origin...aka-Mitochondrial Dysfunction
Mitochondrial Dysfunction and Damage Associated Molecular Patterns (DAMPs) in Chronic Inflammatory Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988941/
I posted information regarding how inhibiting stomach gastrin helps breast growth, but the information on inhibiting gastrin follows the same hypothesis of treating PCOS by inhibiting gastrin
https://www.breastnexus.com/showthread.php?tid=22417&pid=207918&highlight=inflammation#pid207918
Good luck.
L.
And this is where metformin comes in. Metformin lowers the insulin response (or insulin resistance), meaning lowering blood glucose.
But let's back things up for a minute and start with stomach acid. See if the PCOS dysfunction can be controlled it needs to start with inhibiting stomach gastrin.
Metformin has side effects of nausea, diarrhoea, flatulence, bloating, anorexia, metallic taste and abdominal pain.
Metformin stimulates AMP-activated protein kinase (AMPK) and is also referred to as the master regulator of energy homeostasis. There is however a conflict with metformin as it inhibits aromatase (via AMPK production), meaning it inhibits breast growth.
Role of metformin in the management of polycystic ovary syndrome
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3475283/#!po=0.602410
I refer to metformin here because of its action, lowering insulin.
Reducing inflammation can start in the mitochondria, which is its place of origin...aka-Mitochondrial Dysfunction
Mitochondrial Dysfunction and Damage Associated Molecular Patterns (DAMPs) in Chronic Inflammatory Diseases
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988941/
I posted information regarding how inhibiting stomach gastrin helps breast growth, but the information on inhibiting gastrin follows the same hypothesis of treating PCOS by inhibiting gastrin
https://www.breastnexus.com/showthread.php?tid=22417&pid=207918&highlight=inflammation#pid207918
Good luck.
L.