29-03-2019, 20:20
(This post was last modified: 29-03-2019, 20:24 by imbackagain.)
I received my MK 677 in the mail and I was looking into some research on it, and I found this
"Oral estrogen treatment suppresses IGF-1 production in the liver, where approximately 80% of serum IGF-1 originates from,[50] and reduces total serum IGF-1 levels (by 15–40%, dependent on dose and type of estrogen administered), as well as increases levels of insulin-like growth factor-binding protein 1 (IGFBP1) (a carrier protein that inhibits IGF-1 binding/activity).[51] This results in a state of functional GH resistance (as GH induces IGF-1 production and secretion in the liver to mediate most of its effects),[50] with combined oral estrogen and GH being less effective in evoking the clinical effects of GH relative to GH alone in clinical studies of individuals with hypopituitarism/GHD.[51] In contrast, treatment with combined GH and transdermal estrogen has been found not to decrease IGF-1 levels or increase IGFBP1 levels.[51] As such, estrogen administered via other routes of administration that bypass the liver, such as transdermal (in the form of estrogen patches), sublingual, intranasal, intramuscular injection, and subcutaneous injection, may be significantly more effective than oral estrogen.[51]
This makes me wonder... if taking the MK 677 during when you take your BO would work against you? Would it be best to use the MK 677 and only the nipple cream for results? MissMadScientist I believe stopped the nipple cream after hers were even and continued with the MK 677 and the BO orally both at night. I'm not sure if they would cancel each other out. Something to think about.
https://www.ncbi.nlm.nih.gov/pubmed/22108915
"Oral estrogen treatment suppresses IGF-1 production in the liver, where approximately 80% of serum IGF-1 originates from,[50] and reduces total serum IGF-1 levels (by 15–40%, dependent on dose and type of estrogen administered), as well as increases levels of insulin-like growth factor-binding protein 1 (IGFBP1) (a carrier protein that inhibits IGF-1 binding/activity).[51] This results in a state of functional GH resistance (as GH induces IGF-1 production and secretion in the liver to mediate most of its effects),[50] with combined oral estrogen and GH being less effective in evoking the clinical effects of GH relative to GH alone in clinical studies of individuals with hypopituitarism/GHD.[51] In contrast, treatment with combined GH and transdermal estrogen has been found not to decrease IGF-1 levels or increase IGFBP1 levels.[51] As such, estrogen administered via other routes of administration that bypass the liver, such as transdermal (in the form of estrogen patches), sublingual, intranasal, intramuscular injection, and subcutaneous injection, may be significantly more effective than oral estrogen.[51]
This makes me wonder... if taking the MK 677 during when you take your BO would work against you? Would it be best to use the MK 677 and only the nipple cream for results? MissMadScientist I believe stopped the nipple cream after hers were even and continued with the MK 677 and the BO orally both at night. I'm not sure if they would cancel each other out. Something to think about.
https://www.ncbi.nlm.nih.gov/pubmed/22108915