05-12-2016, 16:17
From your mouse/cancer study:
Quote:Prolactin and progesterone may enhance ductal outgrowth by inducing ERa expression. Furthermore, targeted gene deletion in the germ line may mask physiologic functions of a given gene product as mutant tissues may have time during development to compensate for the loss of a particular gene product. Plasticity may result in compensation, and it is conceivable that if a hormone receptor was efficiently abrogated at a later stage, different and/or more severe phenotypes would be discerned.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982168/