11-11-2016, 23:22
(04-09-2016, 23:32)Lotus Wrote: HOPS is 70 times more potent for ER-b (estrogen receptor beta) over estradiol and 20,000 times less potent at ER-a (estrogen receptor alpha) over estradiol. If I didn't mention already HOPS upregulates progesterone receptor mRNA (signaling). Besides stimulating IGF-1 HOPs enhances thermogenesis in BAT (brown adipose tissue, aka " fat " ), which means counteracting increases body fat.
http://www.ncbi.nlm.nih.gov/m/pubmed/26098641/
* I'd take it at night time for the IGF-1 stimulation and promotion of PR (progesterone receptor).
Quote:Hops and red clover extracts, as well as 8-PN upregulated progesterone receptor (PR) mRNA in the Ishikawa cell line.
In the MCF-7 cell line, PR mRNA was significantly upregulated by the extracts, biochanin A, genistein, 8-PN, and IX. The two extracts had EC50 values of 1.1 and 1.9 μg/mL, respectively, in the alkaline phosphatase induction assay. Based on these data, hops and red clover could be attractive for development as herbal dietary supplements to alleviate menopause-associated symptoms.
Comparison of the In Vitro Estrogenic Activities of Compounds from Hops (Humulus lupulus) and Red Clover (Trifolium pratense)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1815392/pdf/nihms14948.pdf