27-04-2016, 22:25
(27-04-2016, 21:20)Lotus Wrote: Lol, you want me to provide (and pay) all the research, too funny.
Nope. Not at all. I was just commenting that that particular synopsis made that research paper sound interesting, and that it was rather unfortunate the rest of it was unavailable, even for money. If you happen to have a link to where the entire paper is available though I wouldn't mind if you provided it. I couldn't find it.
(27-04-2016, 21:20)Lotus Wrote: Coumarin based selective estrogen receptor modulators (SERMs) and coumarin-estrogen conjugates have also been described as potential antibreast cancer agents.
This is about derivatives, not coumarin itself.
(27-04-2016, 21:20)Lotus Wrote: I see coumarins having weak estrogenic potential, (and modulating HPA, SERMS, as stated)
This is about derivatives, not coumarin itself.
(27-04-2016, 21:20)Lotus Wrote: I'd like to see you're research on coumarins having anti-androgens properties (I know it does, still, (I'm curios) what you have.
As I said above, I know I've posted all that I have before, so unless it's been removed like I've noticed some other of my recent posts have been it should be on this forum still somewhere if you search it. Only coumarin has anti-androgenic effects, none of its derivatives do so far as any current research indicates. Except as a side effect from the estrogenic effects of some derivatives.
(27-04-2016, 21:20)Lotus Wrote: There's a lot more to that study then a quick glance of 103 pages. e.g:
For example, coumarin and its active metabolite, 7-hydroxycoumarin, demonstrated growth-inhibitory cytostatic activity in human cancer cell lines, such as A549 (lung), ACHN (renal), H727 (lung), MCF-7 (breast) and HL-60 (leukemia), and have also been reported to demonstrate activity against prostate cancer, malignant melanoma, and metastatic renal cell carcinoma in clinical trials [26–29]
Well, yes, coumarin itself is also anti-cancer. There's a lot more research on coumarin and coumarins and cancer than there is on any other properties of coumarin or coumarins. If that was in that paper and I missed it/forgot it, I apologize for that memory lapse. I've never claimed to have a perfect memory.