20-02-2016, 22:30
Nettle VS Saw Palmetto
June 28 2006 at 6:07 AM
Ada (Login pinktatsu)
EVE MEMBERS
Does nettle root has the same effects in the body as Saw palmetto? Does it helps with the estrogen? Sorry, but i've been reading the posts, but i cant understand all that, im taking fenugreek, fennel, borage oil, and wild yam, and i bought Saw palmetto, but i dont want to take it, because of my birth control , so i was thinking about the nettle root, so i would like to know if it has the same effects than saw palmetto.
Helen
(Login Helen_N)
EVE MEMBERS
Re: Nettle VS Saw Palmetto
June 28 2006, 9:45 AM
Hi Ada
I have read that, for girls with elevated testosterone levels needing DHT-blocking herbs like Saw Palmetto, other alternative herbs that are also appropriate include
stinging Nettle,
Licorice,
Pumpkin Seeds,
Pygeum.
Not sure how different they are in "strength", they do however have similar effect.
Best boobie wishes, Helen xx
wsdm
(Login wsdm)
Re: Nettle VS Saw Palmetto
June 28 2006, 3:30 PM
From what I have learned so far:
Saw Palmetto inhibits an enzyme from converting testosterone to DHT, thus forcing testosterone to convert to estrogen.
Nettle root blocks the binding of hormones such as estrogen to SHBG (sex hormone binding globulin).
Estrogen and SBHG bind together to trigger activity in their target cells.
Nettle root blocks the action of an enzyme that converts testosterone to estrogen
Now as I mentioned before it is important for anyone starting NBE to have a hormone test. See where your levels are at.
If you have low estrogen levels it appears Saw Palmetto is good and nettle may not be so great.
If you have high estrogen levels Saw Palmetto is not so good and Nettle may be beneficial.
cool excerpt from http://www.lef.org/protocols/prtcl-095c.shtml
"Nettle Root Extract Blocks DHT Binding to Prostate Cells
An extract from the nettle root called Urtica dioica has been used extensively in combination with saw palmetto or by itself as a drug to treat BPH. One study showed that after 8 weeks of treatment with 4 capsules of urtica extract, patients experienced an 82% improvement in disorders associated with prostate enlargement (Wolf 1980). Another study showed that those patients with prostate enlargement with Stage I-III hyperplasia (the abnormal multiplication of normal cells that can lead to prostate cancer) experienced an 86% improvement after 3 months of treatment with standardized urtica extract (Maar 1987).
After learning the results of these studies, researchers at St. Luke's Roosevelt Hospital in New York conducted a study to discover the mechanism by which standardized urtica extract relieves the symptoms of BPH. In their published study, the St. Luke's scientists showed that urtica extract inhibits the binding of a testosterone-estrogen-related protein to its receptor site on prostate cell membranes (Hryb et al. 1995).
It is known that when the testosterone metabolite DHT binds to prostate cell membranes, the result is the overproliferation of prostate cells. If cell membrane receptors are blocked, then DHT cannot latch on to the cell. Urtica extract appears to work by preventing the binding of testosterone metabolites to membrane receptor sites on prostate cells.
Saw palmetto and U. dioica are approved drugs in Germany for the treatment of benign prostate enlargement. While urtica is relatively new to Americans, it has been safely and successfully used in Germany for more than a decade."
and http://www.lef.org/magazine/mag99/feb99-bph.html
"Farnsworth notes that, as explained above, SHBG increases with age and "can act like an additional androgen receptor [binding site for androgen]" in the prostate cell. He suggests that, when estrogen binds to SHBG in the cell membrane, a growth factor called IGF-I (insulin-like growth factor I) is synthesized, causing proliferation of epithelial cells in the prostate. This sets the stage for further proliferation when androgens activate binding sites for growth factors. In Farnsworth's language, "estrogen not only directs stromal proliferation and secretion, but also, through IGF-I, conditions the response of epithelium to androgen." Subsequent research suggests that IGF-II, which is less well understood than IGF-I, may also be involved. In addition to its possible role in BPH, recent research indicates that elevated IGF-I levels may be a key predictor of prostate cancer risk. IGF-I may also contribute to the age-related increase in SHBG.
Farnsworth likens the protein SHBG to a hormone, concluding: [SHBG's] newfound capability to evoke BPH and its possible involvement in the transformation of normal to cancer cells by oncogenes calls for increased efforts to understand and manage SHBG and estrogen secretion.
The researchers who discovered the alternative signalling pathway concur: "...antagonism [inhibition] of the pathway by which SHBG leads to the induction of androgen-responsive genes may be a valuable therapeutic target for the treatment or prevention of BPH or prostate cancer."
Accordingly, these researchers studied an agent thought to inhibit the binding of SHBG to the prostate cell membrane, an extract of the root of the stinging nettle plant, Urtica dioica. In a paper published in 1995 in Planta Medica, they demonstrated that nettle root does indeed inhibit the binding of SHBG to the cell membrane.
In a subsequent series of articles, German researchers have identified a constituent of nettle root known as (-)-3,4-divanillyltetrahydrofuran whose very high binding affinity to SHBG they describe as "remarkable." These researchers suggest that the beneficial effects of plant lignans (such as found in flaxseed oil) on hormone-dependent cancers may be linked to their binding affinity to SHBG. The most potent known lignans in this respect are constituents of nettle root.
Studies show that the ethanolic extract of nettle root is not in inhibiting SHBG binding, while the aqueous and methanolic extracts are.
In addition to inhibiting SHBG binding, at least six constituents of nettle root inhibit aromatase, reducing conversion of androgens to estrogens. Combining nettle root with pygeum results in a stronger, synergistic inhibition. The studies on aromatase inhibition by nettle root used methanolic extracts.
A recent experimental study provides a dramatic demonstration of nettle root's effect on BPH tissue. This experiment was based upon the hypothesis that BPH is comparable to a reawakening of embryonic growth potential in the prostate. A fetal urogenital sinus was implanted into a lobe of the prostate gland in adult mice. After 28 days, the implanted lobes of mice fed a nettle root methanolic extract similar to an extract on the German pharmaceutical market showed 51.3% less growth than the lobes of mice in the control group."
June 28 2006 at 6:07 AM
Ada (Login pinktatsu)
EVE MEMBERS
Does nettle root has the same effects in the body as Saw palmetto? Does it helps with the estrogen? Sorry, but i've been reading the posts, but i cant understand all that, im taking fenugreek, fennel, borage oil, and wild yam, and i bought Saw palmetto, but i dont want to take it, because of my birth control , so i was thinking about the nettle root, so i would like to know if it has the same effects than saw palmetto.
Helen
(Login Helen_N)
EVE MEMBERS
Re: Nettle VS Saw Palmetto
June 28 2006, 9:45 AM
Hi Ada
I have read that, for girls with elevated testosterone levels needing DHT-blocking herbs like Saw Palmetto, other alternative herbs that are also appropriate include
stinging Nettle,
Licorice,
Pumpkin Seeds,
Pygeum.
Not sure how different they are in "strength", they do however have similar effect.
Best boobie wishes, Helen xx
wsdm
(Login wsdm)
Re: Nettle VS Saw Palmetto
June 28 2006, 3:30 PM
From what I have learned so far:
Saw Palmetto inhibits an enzyme from converting testosterone to DHT, thus forcing testosterone to convert to estrogen.
Nettle root blocks the binding of hormones such as estrogen to SHBG (sex hormone binding globulin).
Estrogen and SBHG bind together to trigger activity in their target cells.
Nettle root blocks the action of an enzyme that converts testosterone to estrogen
Now as I mentioned before it is important for anyone starting NBE to have a hormone test. See where your levels are at.
If you have low estrogen levels it appears Saw Palmetto is good and nettle may not be so great.
If you have high estrogen levels Saw Palmetto is not so good and Nettle may be beneficial.
cool excerpt from http://www.lef.org/protocols/prtcl-095c.shtml
"Nettle Root Extract Blocks DHT Binding to Prostate Cells
An extract from the nettle root called Urtica dioica has been used extensively in combination with saw palmetto or by itself as a drug to treat BPH. One study showed that after 8 weeks of treatment with 4 capsules of urtica extract, patients experienced an 82% improvement in disorders associated with prostate enlargement (Wolf 1980). Another study showed that those patients with prostate enlargement with Stage I-III hyperplasia (the abnormal multiplication of normal cells that can lead to prostate cancer) experienced an 86% improvement after 3 months of treatment with standardized urtica extract (Maar 1987).
After learning the results of these studies, researchers at St. Luke's Roosevelt Hospital in New York conducted a study to discover the mechanism by which standardized urtica extract relieves the symptoms of BPH. In their published study, the St. Luke's scientists showed that urtica extract inhibits the binding of a testosterone-estrogen-related protein to its receptor site on prostate cell membranes (Hryb et al. 1995).
It is known that when the testosterone metabolite DHT binds to prostate cell membranes, the result is the overproliferation of prostate cells. If cell membrane receptors are blocked, then DHT cannot latch on to the cell. Urtica extract appears to work by preventing the binding of testosterone metabolites to membrane receptor sites on prostate cells.
Saw palmetto and U. dioica are approved drugs in Germany for the treatment of benign prostate enlargement. While urtica is relatively new to Americans, it has been safely and successfully used in Germany for more than a decade."
and http://www.lef.org/magazine/mag99/feb99-bph.html
"Farnsworth notes that, as explained above, SHBG increases with age and "can act like an additional androgen receptor [binding site for androgen]" in the prostate cell. He suggests that, when estrogen binds to SHBG in the cell membrane, a growth factor called IGF-I (insulin-like growth factor I) is synthesized, causing proliferation of epithelial cells in the prostate. This sets the stage for further proliferation when androgens activate binding sites for growth factors. In Farnsworth's language, "estrogen not only directs stromal proliferation and secretion, but also, through IGF-I, conditions the response of epithelium to androgen." Subsequent research suggests that IGF-II, which is less well understood than IGF-I, may also be involved. In addition to its possible role in BPH, recent research indicates that elevated IGF-I levels may be a key predictor of prostate cancer risk. IGF-I may also contribute to the age-related increase in SHBG.
Farnsworth likens the protein SHBG to a hormone, concluding: [SHBG's] newfound capability to evoke BPH and its possible involvement in the transformation of normal to cancer cells by oncogenes calls for increased efforts to understand and manage SHBG and estrogen secretion.
The researchers who discovered the alternative signalling pathway concur: "...antagonism [inhibition] of the pathway by which SHBG leads to the induction of androgen-responsive genes may be a valuable therapeutic target for the treatment or prevention of BPH or prostate cancer."
Accordingly, these researchers studied an agent thought to inhibit the binding of SHBG to the prostate cell membrane, an extract of the root of the stinging nettle plant, Urtica dioica. In a paper published in 1995 in Planta Medica, they demonstrated that nettle root does indeed inhibit the binding of SHBG to the cell membrane.
In a subsequent series of articles, German researchers have identified a constituent of nettle root known as (-)-3,4-divanillyltetrahydrofuran whose very high binding affinity to SHBG they describe as "remarkable." These researchers suggest that the beneficial effects of plant lignans (such as found in flaxseed oil) on hormone-dependent cancers may be linked to their binding affinity to SHBG. The most potent known lignans in this respect are constituents of nettle root.
Studies show that the ethanolic extract of nettle root is not in inhibiting SHBG binding, while the aqueous and methanolic extracts are.
In addition to inhibiting SHBG binding, at least six constituents of nettle root inhibit aromatase, reducing conversion of androgens to estrogens. Combining nettle root with pygeum results in a stronger, synergistic inhibition. The studies on aromatase inhibition by nettle root used methanolic extracts.
A recent experimental study provides a dramatic demonstration of nettle root's effect on BPH tissue. This experiment was based upon the hypothesis that BPH is comparable to a reawakening of embryonic growth potential in the prostate. A fetal urogenital sinus was implanted into a lobe of the prostate gland in adult mice. After 28 days, the implanted lobes of mice fed a nettle root methanolic extract similar to an extract on the German pharmaceutical market showed 51.3% less growth than the lobes of mice in the control group."