28-01-2016, 14:03
question for any research guru's?
June 5 2006 at 5:52 AM Tap (Login Tap69)
EVE MEMBERS
hi girls, as some of you know I'm experimenting with Pueraria mirifica in my new routine.
Many PM sites recommend that calcium suppliments are taken with it to "enhance the effectiveness". I;ve been wondering why this is the case? I did some poking around and found a research paper that i'm having trouble understanding. The experiment is conducted on menopausal cynomolgus monkeys (poor girls), even though i am not a "menopausal monkey" (unless i skipped waxing for a few months), i still want to understand the research conclusions.
Anyone interested in a challenge??
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15647615&dopt=Abstract
Love ya all
Tap
twilightsrose
(no login)
Re: question for any research guru's?
June 5 2006, 8:01 AM
Here a summary with some definitions:
Parathyroid Hormone: PTH acts to increase the concentration of calcium in the blood in three ways. It enhances the release of calcium from the large reservoir contained in the bones, enhances reabsorption of calcium from renal tubules; and enhances the absorption of calcium in the intestine by increasing the production of vitamin D and upregulating the enzyme responsible for 1-alpha hydroxylation of 25-OH vitamin D converting vitamin D to its active form (1,25-OH vitamin D) which effects the actual absorption of calcium by the intestine.
PTH also acts to decrease the concentration of phosphate in the blood, primarily by reducing reabsorption in the proximal tubules of the kidney.
Increased calcium concentration in the blood acts (via feedback inhibition) to decrease PTH secretion by the parathyroid glands. This is achieved by the activation of calcium-sensing receptors located on parathyroid cells
In other words, if your body releases too much parathyroid hormone, such as with parathyroid disease, it releases too much calcium from the bones into the blood resulting in bone density loss (osteoporosis).
The results from the research paper indicates that the highest dosage of PM reduces PTH levels, which results in lowered blood calcium, perhaps reversing bone loss. (ameliorate means to make better/to improve)
Tap
(Login Tap69)
EVE MEMBERS
research guru
June 5 2006, 11:05 AM
thanks.. i understand better.
So the recommendation of taking extra calcium with the PM, hasn't to do with breast growth, but about the benefits to hair and nails (when increased estrogen and calcium and present).
If this is the case, I might not need these calcium suppliments for my nbe program.
June 5 2006 at 5:52 AM Tap (Login Tap69)
EVE MEMBERS
hi girls, as some of you know I'm experimenting with Pueraria mirifica in my new routine.
Many PM sites recommend that calcium suppliments are taken with it to "enhance the effectiveness". I;ve been wondering why this is the case? I did some poking around and found a research paper that i'm having trouble understanding. The experiment is conducted on menopausal cynomolgus monkeys (poor girls), even though i am not a "menopausal monkey" (unless i skipped waxing for a few months), i still want to understand the research conclusions.
Anyone interested in a challenge??
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15647615&dopt=Abstract
Love ya all
Tap
twilightsrose
(no login)
Re: question for any research guru's?
June 5 2006, 8:01 AM
Here a summary with some definitions:
Parathyroid Hormone: PTH acts to increase the concentration of calcium in the blood in three ways. It enhances the release of calcium from the large reservoir contained in the bones, enhances reabsorption of calcium from renal tubules; and enhances the absorption of calcium in the intestine by increasing the production of vitamin D and upregulating the enzyme responsible for 1-alpha hydroxylation of 25-OH vitamin D converting vitamin D to its active form (1,25-OH vitamin D) which effects the actual absorption of calcium by the intestine.
PTH also acts to decrease the concentration of phosphate in the blood, primarily by reducing reabsorption in the proximal tubules of the kidney.
Increased calcium concentration in the blood acts (via feedback inhibition) to decrease PTH secretion by the parathyroid glands. This is achieved by the activation of calcium-sensing receptors located on parathyroid cells
In other words, if your body releases too much parathyroid hormone, such as with parathyroid disease, it releases too much calcium from the bones into the blood resulting in bone density loss (osteoporosis).
The results from the research paper indicates that the highest dosage of PM reduces PTH levels, which results in lowered blood calcium, perhaps reversing bone loss. (ameliorate means to make better/to improve)
Tap
(Login Tap69)
EVE MEMBERS
research guru
June 5 2006, 11:05 AM
thanks.. i understand better.
So the recommendation of taking extra calcium with the PM, hasn't to do with breast growth, but about the benefits to hair and nails (when increased estrogen and calcium and present).
If this is the case, I might not need these calcium suppliments for my nbe program.