[AbiDrew85]

Welcome back to the forum.


The side effects seem to be extreme ?

https://en.m.wikipedia.org/wiki/Coumarin

What are you referring to? This?

Coumarin is moderately toxic to the liver and kidneys, with a median lethal dose (LD50) of 275 mg/kg

That's very very high. The effective dose for destroying AR receptors is only 40mg/kg, well below median toxicity. It's just EXPENSIVE even in much lower doses than are medicinally effective, due to being slightly controlled like it is.

Other than that, all its other effects are purely in the plus category. If you suffer various ailments it is medicinal towards, benefit, if not, no harm done. Harm is only done if you get close to 275mg/kg. To put THAT in perspective, let's say you're an exceptionally tiny person and only weigh 90 lbs. That converts to a little less that 41 kg. We'll use 40 to be safe. You'd need to consume 1.75 KILOGRAMS of bean to reach toxicity. That's almost 4 pounds. That'd be closer to 200 dollars, consumed beans worth that much, all at once, to risk toxicity.

By the way. Almost anything is toxic to the liver if you eat too much. While the liver toxicity is high compared to many other foods, even fish oil is higher still. Almost anything you could drink except water is potentially toxic to the kidneys. And many foods are too if they aren't water soluble yet still able to reach the kidneys. Kidneys flush water soluble materials as part of their design, but they have to absorb anything else that reaches them, which can lead to toxicity.

Toxicity with reishi is MUCH easier to reach due to mycotoxins. Coumarin is the ONLY medicinally active compound in tonka beans.

EDIT: accidentally stated the effective dose was 35, it's 40. Actually it BEGINS to be effective as low as 20, but it's peak effectiveness is at 40. It drops off both below and above that dose.