02-06-2015, 21:26
Prolactin stimulates breast growth in the presence of high estrogens, progesterone and estrogen stimulate growth too, and from what I've seen (still needs to be verified) pharma progestins up-regulate IGF-1. However, imo peptides look very promising.
![[Image: attachment.php?aid=9684]](http://www.breastnexus.com/attachment.php?aid=9684)
Hormone-Dependent Mammary Gland Development
Hormone-dependent mammary gland development occurs after puberty and results in ductal elongation; recurrent estrous cycles in adulthood trigger side branching; pregnancy enhances side branching and induces alveolo- genesis with lactational differentiation followed by involution at weaning (Brisken 2002). In the late fifties, a series of experiments defined the minimal hormonal requirements for mammary gland development in mice (Nandi 1958) and rats (Lyons 1958). Endocrine ablation was achieved by surgically removing the major sources of reproductive hormones from mature females, the ovaries, which secrete estrogens and progesterone, the pituitary gland, a major source of growth hormone (GH) and prolactin (Prl), and for some experiments the adrenal glands, which release cortisol and precursors of sex steroids (see Fig. 1). Hormone replace- ment in hormone-deprived animals established that additive and sequential treatment with 17-b-estradiol, progesterone, and prolactin in conjunction with cortisol and GH can recapitulate mammary gland development.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982168/pdf/cshperspect-MAM-a003178.pdf
Hormone-Dependent Mammary Gland Development
Hormone-dependent mammary gland development occurs after puberty and results in ductal elongation; recurrent estrous cycles in adulthood trigger side branching; pregnancy enhances side branching and induces alveolo- genesis with lactational differentiation followed by involution at weaning (Brisken 2002). In the late fifties, a series of experiments defined the minimal hormonal requirements for mammary gland development in mice (Nandi 1958) and rats (Lyons 1958). Endocrine ablation was achieved by surgically removing the major sources of reproductive hormones from mature females, the ovaries, which secrete estrogens and progesterone, the pituitary gland, a major source of growth hormone (GH) and prolactin (Prl), and for some experiments the adrenal glands, which release cortisol and precursors of sex steroids (see Fig. 1). Hormone replace- ment in hormone-deprived animals established that additive and sequential treatment with 17-b-estradiol, progesterone, and prolactin in conjunction with cortisol and GH can recapitulate mammary gland development.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2982168/pdf/cshperspect-MAM-a003178.pdf