[Lotus]

Got another one for you please..

hormonal influence if any on DGL LICORICE extract?

Im interested in it for its intestinal healing properties as its ranked up there on top and was concerned about blood pressure rising but they say its not relevant to DGL just only whole licorice.
But what about estrogen?

What many don't know about phytoestrogens is that in some forms it's stronger than E2- Estradiol, where one can find what's used in HRT.

Say ain't so! Yup, it's true.

Hey we have a winner,!!!



http://www.ncbi.nlm.nih.gov/pmc/articles...po=7.50000

Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra)


Several fractions displayed higher responses than the maximum response obtained with the reference compound, the natural hormone 17β-estradiol (E2).


The roots of licorice are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene. Fractionation of an ethyl acetate extract from licorice root by centrifugal partitioning chromatography yielded 51 fractions.
One third of the fractions displayed estrogenic activity towards either one or both estrogen receptors (ERs; ERα and ERβ). Glabrene-rich fractions displayed an estrogenic response, predominantly to the ERα. Surprisingly, glabridin did not exert agonistic activity to both ER subtypes. Several fractions displayed higher responses than the maximum response obtained with the reference compound, the natural hormone 17β-estradiol (E2). The estrogenic activities of all fractions, including this so-called superinduction, were clearly ER-mediated, as the estrogenic response was inhibited by 20–60% by known ER antagonists. Most fractions displaying superinduction were rich in flavonoids with single prenylation. Glabridin displayed ERα-selective antagonism, similar to the ERα-selective antagonist RU 58668. Whereas glabridin was able to reduce the estrogenic response of E2 by approximately 80% at 6 × 10−6 M, glabrene-rich fractions only exhibited agonistic responses, preferentially on ERα.