[Lotus]

It's a poor analogy here, but hey, I'm a dude, so....and a car lover.

We change our oil every 3000 miles right? So, same principal. Cycling allows the receptors to fine tune or unclog with excess E and xenoestrogens. If we don't cycle the E it gets re-absorbed back into our system and possibly becoming carcinogenic.

DIM, vitex, lemon water, cabbage, broccoli, avocados are just a few tools we have at our disposal for healthly E metabolism. (Exercise, massage and filtered water too).

Cycling oil in your car would entail driving around with no oil for part of the time and damage the engine. Receptors don't get clogged by high estrogen, they get desensitized. Cycling restores receptor sensitivity. It's the same principle as why pirates wore eye patches. The covered eye becomes more sensitive to light and has great vision for when they go below decks into darkness and flip up the patch.

Cycling will not prevent enterohepatic reabsorption of estrogens. For that you need calcium D-glucarate. The liver conjugates estrogens with glucuronic acid and excretes them into the intestine with the bile. Intestinal bacteria can make the enzyme beta-glucuronidase which unconjugates the estrogen and allows it to be reabsorbed. D-glucarate inhibits beta glucuronidase and thus prevents estrogen reabsorption.

DIM is for ensuring that estrogen metabolism follows the C2 pathway and not the C16 pathway which makes carcinogens.

I said change the oil, not run without it. Which would obviously signal the lack of understanding of what a maintenance plan is. It's just an simple analogy for the OP, NOT for YOU, get over yourself.

Why improving receptor sensitivity is important for NBE,


Regulation of hormone receptors is very important for a normal functioning cell. There are several ways a cell regulates its hormone receptors. Below is an outline of such regulatory functions:

Regulating the expression of receptors - changing the number of receptors on the plasma membrane.
1. Up regulation - increasing the number of receptors
2. Down regulation - decreasing the number of receptors

Mechanism:
-internalization - endocytosis of receptors
-modify transcription - inhibiting or stimulating transcription factors
-modify receptor half-life - adding groups to the receptors which will degrade them faster


Downregulation is the process by which a cell decreases the quantity of a cellular component, such as RNA or protein, in response to an external variable. An increase of a cellular component is called upregulation.

An example of downregulation is the cellular decrease in the number of receptors to a molecule, such as a hormone or neurotransmitter, which reduces the cell's sensitivity to the molecule. This phenomenon is an example of a locally acting negative feedback mechanism.

An example of upregulation is the increased number of cytochrome P450 enzymes in liver cells when xenobiotic molecules such as dioxin are administered (resulting in greater degradation of these molecules).

Most receptor agonists downregulate their respective receptor(s), while most receptor antagonists upregulate their respective receptor(s). The disequilibrium caused by these changes often causes withdrawal when the long-term use of a medication or drug is discontinued. However, the chronic use of certain receptor antagonists may also damage receptors faster than they upregulate.

Upregulation and downregulation can also happen as a response to toxins or hormones. An example of upregulation in pregnancy is hormones that cause cells in the uterus to become more sensitive to oxytocin.

An agonist is a chemical that binds to a receptor and activates the receptor to produce a biological response. Whereas an agonist causes an action, an antagonist blocks the action of the agonist and an inverse agonist causes an action opposite to that of the agonist.





Downregulation and upregulation
http://wikipedia.org/wiki/Downregulation_and_upregulation

Any questions?,

Question- what triggers tissue growth in order for NBE to work?