05-10-2014, 04:26
Quote"
results verified that the activity of the chimeric receptor construct in the presence of DHT and DIM was similar to activity of the simple pCMV-AR-derived receptor (data not shown). These results show that DIM both inhibits the nuclear translocation of the liganded AR and prevents the formation of nuclear AR foci.
Structural Modeling of DIM Binding to the AR and Comparison with DHT, R1881, and Casodex—Because DIM is a strong antagonist of AR function but exhibits less than obvious structural similarity to the endogenous AR ligand, DHT, we compared the structure of DIM to DHT and other AR ligands.
End Quote"
HUH?????????? What the H*LL us linganded AR, sounds like what a zombie catches while engaging a hooker. And foci, sounds like a new Italian bread dough.... Sorry, I am not a 5th yr Chemistry major only High School..... LOL sheesh. Could you translate please? Or someone?
These results indicate that DIM might mediate an early block in androgen action, including the inhibition of heat shock protein dissociation from the AR and/or a masking of the nuclear translocation signal.
http://www.jbc.org/content/278/23/21136.full
results verified that the activity of the chimeric receptor construct in the presence of DHT and DIM was similar to activity of the simple pCMV-AR-derived receptor (data not shown). These results show that DIM both inhibits the nuclear translocation of the liganded AR and prevents the formation of nuclear AR foci.
Structural Modeling of DIM Binding to the AR and Comparison with DHT, R1881, and Casodex—Because DIM is a strong antagonist of AR function but exhibits less than obvious structural similarity to the endogenous AR ligand, DHT, we compared the structure of DIM to DHT and other AR ligands.
End Quote"
HUH?????????? What the H*LL us linganded AR, sounds like what a zombie catches while engaging a hooker. And foci, sounds like a new Italian bread dough.... Sorry, I am not a 5th yr Chemistry major only High School..... LOL sheesh. Could you translate please? Or someone?
These results indicate that DIM might mediate an early block in androgen action, including the inhibition of heat shock protein dissociation from the AR and/or a masking of the nuclear translocation signal.
http://www.jbc.org/content/278/23/21136.full