05-10-2014, 03:27
Apologies to OP, this is off topic,
The study below confirms that DIM inhibits DHT, honestly, I forgot about DIM being an anti-androgen. Some results are mixed on the side effetcs of DIM, (SO MAKE SURE YOU DO THE RESEARCH), Although you can find a jack pot of info on THE BREASTNEXUS SEARCH OPTION.
results verified that the activity of the chimeric receptor construct in the presence of DHT and DIM was similar to activity of the simple pCMV-AR-derived receptor (data not shown). These results show that DIM both inhibits the nuclear translocation of the liganded AR and prevents the formation of nuclear AR foci.
Structural Modeling of DIM Binding to the AR and Comparison with DHT, R1881, and Casodex—Because DIM is a strong antagonist of AR function but exhibits less than obvious structural similarity to the endogenous AR ligand, DHT, we compared the structure of DIM to DHT and other AR ligands.
These results indicate that DIM might mediate an early block in androgen action, including the inhibition of heat shock protein dissociation from the AR and/or a masking of the nuclear translocation signal.
http://www.jbc.org/content/278/23/21136.full
credit monika 12/2013 for the link.
Same study
http://www.ncbi.nlm.nih.gov/pubmed/12665522?dopt=Abstract
Health Benefits of Diindolylmethane (Estrogen Metabolism)
http://altmedicine.about.com/od/herbsupplementguide/a/Diindolylmethane.htm
The study below confirms that DIM inhibits DHT, honestly, I forgot about DIM being an anti-androgen. Some results are mixed on the side effetcs of DIM, (SO MAKE SURE YOU DO THE RESEARCH), Although you can find a jack pot of info on THE BREASTNEXUS SEARCH OPTION.
results verified that the activity of the chimeric receptor construct in the presence of DHT and DIM was similar to activity of the simple pCMV-AR-derived receptor (data not shown). These results show that DIM both inhibits the nuclear translocation of the liganded AR and prevents the formation of nuclear AR foci.
Structural Modeling of DIM Binding to the AR and Comparison with DHT, R1881, and Casodex—Because DIM is a strong antagonist of AR function but exhibits less than obvious structural similarity to the endogenous AR ligand, DHT, we compared the structure of DIM to DHT and other AR ligands.
These results indicate that DIM might mediate an early block in androgen action, including the inhibition of heat shock protein dissociation from the AR and/or a masking of the nuclear translocation signal.
http://www.jbc.org/content/278/23/21136.full
credit monika 12/2013 for the link.
Same study
http://www.ncbi.nlm.nih.gov/pubmed/12665522?dopt=Abstract
Health Benefits of Diindolylmethane (Estrogen Metabolism)
http://altmedicine.about.com/od/herbsupplementguide/a/Diindolylmethane.htm