[Lotus]

Just the thread I needed. I was just wondering about the long loop negative feedback mechanism and how it woukd be effected by the herbs I am taking. High levels of estrogen leads to -ve feedback of FSH. So if a person is taking PM or anything that induces estrogen in the body, wouldn't that cause FSH levels to drop causing in the inhibition of your own hormones? Wouldn't that have a bad side effect in the long run?

Hi AA, (apologies for the lengthy reply)

Technically, it's more of a response seen in estrogen receptors, maintaining hemostasis is ideally the outcome (no gaurentees, especially if a thyroid issue exists).

Do you mean after ovulation when progesterone is produced?, which at that point causes a negative feedback mechanism that shuts down FSH secretion.


Well, here's some great reference stuff:

Control of Endocrine Activity
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/basics/control.html


Gonadotropins: Luteinizing and Follicle Stimulating Hormones
http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/hypopit/lhfsh.html

So if a person is taking PM or anything that induces estrogen in the body, wouldn't that cause FSH levels to drop causing in the inhibition of your own hormones? Wouldn't that have a bad side effect in the long run?

I'd say this one could be problematic, meaning everyone is gonna be different. Lab work will confirm test results (if inclined to do so) and then we'd have to assume testing would be free of PM or BC just to get a baseline (like I said, problematic).

Miroestriol and the stronger Dexymiroestrol (Boob growth initiators of PM) has to have a metabolic activation. ( The chemical alteration of an exogenous substance by or in a biological system.)

There was a study of an undisclosed amount of perimenopausal women where they found the mean serum estradiol was slightly increased using a dose of 100 mg's of PM, while the mean serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were nearly stable. And their conclusion was that Pueraria mirifica was relatively safe and preliminarily alleviated the climacteric symptoms in perimenopausal women, but the data is insufficient to draw definite conclusions regarding the estrogenic effects.

Challenges in the conduct of Thai herbal scientific study: efficacy and safety of phytoestrogen, pueraria mirifica (Kwao Keur Kao), phase I, in the alleviation of climacteric symptoms in perimenopausal women.
http://www.ncbi.nlm.nih.gov/pubmed/17710964

   

Sorry, I make the eyes bleed.

Hormones of the Reproductive System
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/SexHormones.html