[peggy]

In human interventions, doses up to 50mg have been used in interventions with no significant reported side-effects[34][29] and doses in the range of 25-100mg in open-label studies lasting up to 6 months have failed to show any relevant toxic effects.[26][27]

Currently no significant side-effects associated with supplemental Pueraria Mirifica at the standard supplemental dosages

Source: http://examine.com/supplements/Pueraria+mirifica/

In german: In niedrigen Dosen sind also keine NW zu befürchten. Weiter im Text steht auch, dass PM bei Tierversuchen in niedrigen Dosen antimutagen gewirkt hat, allerdings kann es bei extrem hohen Dosen (mehrere 1000 mg am Tag) mutagen wirken.

In an Ames test, it appears that Pueraria (Mirifica and Lobata) do not possess any direct mutagenic effects regardless of whether or not they are bioactivated via S9 (to mimic cellular metabolism), but both were slightly antimutagenic when mutations were induced by either benzo(a)pyrene or 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide; lack of mutagenicitiy was seen with 300mg/kg oral ingestion in rats[62] although another study in male mice using higher doses of a water extract (600-800mg/kg, human equivalent dose of 96-128mg/kg) was able to induce a higher frequency of micronuclei formation, indicative of mutagenicity

In german: Das Ganze ist etwas schwer zu verstehen aber die Quelle ist auf jeden Fall vertrauenswürdig und unabhängig.