[Lotus]

No, I cannot remember.

Ok, follow me I you will please......

So you take a supplement and it gets gobbled up in your liver, aka (1st pass).

Drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.

This next part was posted sometime ago but keep it in mind:

Ok, understanding how your herbals diffuse might help explain why some may have a harder time with absorption. We mentioned before a few things about ways to affect the absorption, without getting too technical lets try to explain a few basics.

1) First is A.D.M.E.,

• Absorption - the process of a substance entering the blood circulation.
  
• Distribution - the dispersion or dissemination of substances throughout the fluids and tissues of the body.
  
• Metabolization (or biotransformation, or inactivation) – the recognition by the organism that a foreign substance is present and the irreversible transformation of parent compounds into daughter metabolites.
  
• Excretion - the removal of the substances from the body. In rare cases, some drugs irreversibly accumulate in body tissue.
  

The four criteria all influence the drug levels and kinetics of drug exposure to the tissues and hence influence the performance and pharmacological activity of the compound as a drug. (Obviously it herbs)