04-12-2011, 01:28 AM
Soy has an estrogenic effect at 150 or 300 ppm genistein in the diet, but not at 15 ppm:
http://cancerres.aacrjournals.org/conten...5045.short
In the USDA list in the above post, the genistein contents in the soy milk samples is around 1 mg per 100 g, or 10 ppm. So even drinking soy milk all day is an ineffective dose.
The genistein contents in the soy flour samples are around 90 mg per 100 g, or 900 ppm. That dilutes to 150 ppm if soy meal is 1/6 of the diet. The ineffective dose of 15 ppm is then 1/60 of the whole diet. Eve M took 1,000 mg a day. I'm sure that was nowhere near 1/6 or 1/60 of her diet.
So according to this publication, the effective dose is very high. The research on humans is very different: one to three cups of soy milk is effective, or even high.
In the cosupplementation study, 6 mg genistein was used three times a day:
http://jn.nutrition.org/content/139/12/2293.full
18 mg is 1/5 of 90 mg, so it corresponds to 20 g soy meal, 20 times more than Eve M used.
So the doses from literature vary over a wide range, with Eve M's dose in the middle.
http://cancerres.aacrjournals.org/conten...5045.short
In the USDA list in the above post, the genistein contents in the soy milk samples is around 1 mg per 100 g, or 10 ppm. So even drinking soy milk all day is an ineffective dose.
The genistein contents in the soy flour samples are around 90 mg per 100 g, or 900 ppm. That dilutes to 150 ppm if soy meal is 1/6 of the diet. The ineffective dose of 15 ppm is then 1/60 of the whole diet. Eve M took 1,000 mg a day. I'm sure that was nowhere near 1/6 or 1/60 of her diet.
So according to this publication, the effective dose is very high. The research on humans is very different: one to three cups of soy milk is effective, or even high.
In the cosupplementation study, 6 mg genistein was used three times a day:
http://jn.nutrition.org/content/139/12/2293.full
18 mg is 1/5 of 90 mg, so it corresponds to 20 g soy meal, 20 times more than Eve M used.
So the doses from literature vary over a wide range, with Eve M's dose in the middle.