Hello, I hope this information helps.
(10-01-2023, 06:55 AM)Lotus Wrote: Hi Wheyfu, here's some info on white peony...a little technical yes, but it's what you need to know when ordering WP. Vitamin D3 is a better potentiator than GABA. If you were using BCP or progesterone cream then I'd suggest using GABA as the former depletes allopregnanolone...which can lead to depression. If spearmint doesn't work try reishi mushroom, but don't use saw palmetto...it inhibits progesterone receptors and it's antiestrogenic...especially when used with BCP. It also increases triglycerides, which you'll hear reviews statements of getting cellulite when using SP.
Reishi significantly reduced levels of 5-alpha reductase, preventing conversion of testosterone into the more potent DHT. High levels of DHT are a risk factor for conditions such as benign prostatic hypertrophy (BPH), acne, and baldness.
White Peony – Estrogenic, blocks 5ar and pro-aromatase - Strong.
A compound found in white peony inhibits the production of testosterone and promotes the activity of aromatase, which converts testosterone into estrogen.
From the research I've covered, Reishi Inhibits type I & II 5ar....and WP binds androgen receptors. When I took Reishi I could go 4-5 days without needing a shave. Now, on HRT I need a shave within 2 days...and that's with my T and free T being non-existent, so go figure.
WP needs to be standardized to contain a minimum of 10% Paeoniflorin. Total glucosides of peony (TGP), contains more than 15 components, BUT Paeoniflorin is the most abundant ingredient and NEEDS to be 90% of the total glucosides.
There's about a gazillion scientific papers on WP and its benefits. I've posted most of what I think is beneficial for NBE here (at BN). In the BN search engine, insert Lotus into the username and check the box for posts (not threads) and you find what I've shared.
Using WP and Reishi together works synergistically IMHO.
I had WP and Reishi in my NBE program. In Chinese herbal medicine WP with Reishi pairs the two as a synergy. Reishi inhibits DHT while WP promotes aromatase (inhibits DHT too).
Someone shared the WP content of Swanson's brand a while back (my apologies to the OP I don't remember who though). White peony (standardized) should bump aromatase 2-3 fold (based on scientific literature). I believe Life Extension sells a standardized capsule but Swanson full spectrum isn't standardized.
WP supplement contains two compounds: 6'-O-galloyl albiflorum and pentagalloylglucose, they bind androgen receptors and inhibit DHT. The dose of these compounds (and the main glycoside 3'-O-galloyl paeoniflorin) are present would be estimated @ 3 grams.
Additionally, testosterone/delta 4-androstenedione production ratio is also reduced (significantly) by paeoniflorin (white peony).
So, in ovaries WP promotes aromatase, (I believe in the breasts too), inhibits DHT in sebum, inhibits prostate cancer cells, (which means it inhibits C17 @ CYP17 P450 enzyme, a strong anti-androgen. The lab dosage was 2 grams (I'll have to double check). Roots be king.
Androgen modulators from the roots of Paeonia lactiflora (paeoniae radix) grown and processed in nara prefecture, Japan.
Washida K1, Itoh Y, Iwashita T, Nomoto K.
Author information
Abstract
The monoterpene glycoside, 3'-O-galloyl paeoniflorin (1), and four known compounds, 6'-O-galloyl albiflorum (2), pentagalloylglucose (3), 6'-O-benzoyl paeoniflorin (4) and 6'-O-galloyl paeoniflorin (5), were isolated from the roots of Paeonia lactiflora that had been grown and processed in Nara prefecture, Japan, as androgen modulators. Their structures were elucidated based on spectroscopic analysis. Compounds 2 and 3 showed strong androgen receptor (AR) binding activity (IC(50) values 33.7 and 4.1 microg/ml, respectively), 1, 4 and 5 showed weak activity (20, 31 and 12% at 120 microg/ml, respectively). However, paeoniflorin (6) and albiflorin (7), the structures of which are related to 1, 2, 4 and 5, showed no activity. These results suggested that both the structure of albiflorin and the galloyl moiety are important for 2 to show strong AR binding activity. Furthermore, compounds 1-5 inhibited growth of an androgen-dependent LNCaP-FGC (prostate cancer cell line), and were indicated to be AR antagonists. Compounds 2 and 3 might be candidates as safe, natural anti-androgens.
Testosterone/delta 4-androstenedione production ratio was lowered significantly by paeoniflorin, and two compounds, 6'-O-galloyl albiflorum and pentagalloylglucose bind androgen receptors and inhibit DHT.
