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Hi all,

Isabelle and I were talking about all the different estrogens (see her link for more info very interesting http://www.breastnexus.com/showthread.php?tid=8419&page=30 ), which lead me to read how important aromatase, which lead me to SHBG and I read this. not sure if this is any interest to anyone but I thought it was interesting enough to post:

SHBG's may be lowered by two of the artificially generated progesterones, norgestrel and norethisterone. If you are a woman who may be susceptible to androgenetic alopecia, that is, hereditary hair loss (female pattern baldness), or you have a naturally low SHBG level, you should avoid any contraceptive pills or hormone replacement therapy that contains synthetic progesterone.
http://www.digitalnaturopath.com/cond/C655233.html

Hey Isabelle did I get that connection right and what herbs, foods, supps, block aromatase and SHBG..
Flax inhibits aromatase a little, and increases SHBG. Fish oil and oats decrease SHBG. Eating fast carbs releases insulin. Insulin binds to SHBG. So less SHBG is left to bind testosterone. That increases free testosterone.
(30-08-2011, 09:40 PM)Isabelle Wrote: [ -> ]Flax inhibits aromatase a little, and increases SHBG. Fish oil and oats decrease SHBG. Eating fast carbs releases insulin. Insulin binds to SHBG. So less SHBG is left to bind testosterone. That increases free testosterone.

what about herbs..does FG low SHBG and what raises them..
FG releases insulin too, and that binds to SHBG.

The only way I know to increase SHBG is flax.
Some very interesting stuff plus read way down in the color print about caffeine can be good to have your cup of coffee...yeah and green tea tooRolleyes (I personally dont like it).


The Importance of High Levels of
Estradiol


• Overweight men and women often
and predictably have high blood levels
of estradiol (E2)
– Fat cells produce the “aromatase enzyme”,
which rapidly converts testosterone into
estrogen
– People with excessive body fat, especially
abdominal fat, are likely to have increased
estrogen levels caused by:
• Aromatase activity
• Dramatically increased estrogen level
compared to testosterone
• Important note: Testosterone is a precursor to
estrogen, and DHEA is the precursor to testosterone

Lowering Cortisol

• Excessive cortisol can block
progesterone receptors, making
them less responsive to
progesterone
• It’s all about balance and ratio
Progesterone
Cortisol
Optimal Estradiol/Progesterone Ratio: 10:1
STRESS


Fat Cells

• Rising estrogen (E2) levels increase SHBG (sex
hormone binding globulin) levels
– SHBG ties up and inactivates all sex hormones; i.e.,
testosterone, estrogen, progesterone, etc.
– When an estrogen molecule occupies a testosterone
receptor site on a cell membrane, it blocks the ability
of serum testosterone to receive a healthy hormonal
signal
• So it does not matter how much serum free
testosterone is available if excess estrogen is
competing for the same cellular receptor sites

Benefits of Progesterone

• Helps use fat for energy
• A natural diuretic
• A natural
antidepressant
• Calms anxiety
• Prevents cyclical
migraines
• Promotes normal sleep
patterns
• Facilitates thyroid
hormone
• Helps restores normal
libido
• Helps prevent breast
cancer
• Decreased risk of
prostate cancer
• Stimulates new bone
formation
– The only hormone that
lays down bone

Progesterone Deficiency

• Progesterone: At the very top of an important
metabolic pathway
• Deficiency leads to reduction of both
glucocorticostroids and mineralcorticoids,
such as cortisol
• Symptoms include high blood pressure and
mineral imbalances
– Progesterone supplementation often effectively
resolves the problems

Progesterone

• Progesterone is important in down-regulating
DHT synthesis from testosterone
• Made in the liver from cholesterol
– In men, most of the progesterone is from the
adrenal gland
• Progesterone-estrogen imbalance can
interfere with thyroid function as well as
result from diminished thyroid function

Low Progesterone Symptoms

• Headaches
• Anxiety
• Cramping
• Infertility
• Acne
• Weight gain
• Low libido
• Depression (progesterone deficiency & excess)
• PMS
• Fuzzy thinking
• Joint pain

Here is the link I found this..alot more then that..
http://wellness.med.miami.edu/documents/...Greer).pdf

Found this about caffeine..green tea and coffee:

Association of coffee, green tea, and caffeine intakes with serum concentrations of estradiol and sex hormone-binding globulin in premenopausal Japanese women.
Nagata C, Kabuto M, Shimizu H.
Department of Public Health, Gifu University School of Medicine, Japan. chisato@cc.gifu-u.ac.jp

Caffeine intake has been proposed to influence breast cancer risk. Its effect may be mediated by hormonal changes. The relationships between caffeine-containing beverages (coffee, green tea, black tea, oolong tea, and cola) and serum concentrations of estradiol and sex hormone-binding globulin were evaluated in 50 premenopausal Japanese women. Intakes of caffeine and caffeine-containing beverages were assessed by a semiquantitative food-frequency questionnaire. Blood samples were obtained from each woman on Days 11 and 22 of her menstrual cycle. High intakes of caffeinated coffee, green tea, and total caffeine were commonly correlated with increasing sex hormone-binding globulin on Days 11 and 22 of the cycle after controlling for potential confounders [Spearman correlation coefficients ® ranged from 0.23 to 0.31]. Green tea but not caffeinated coffee intake was inversely correlated with estradiol on Day 11 of the cycle (r = -0.32, p = 0.04). Although the effect of caffeine cannot be distinguished from effects of coffee and green tea, consumption of caffeine-containing beverages appeared to favorably alter hormone levels associated with the risk of developing breast cancer.


Green tea:

There is a clinically established inverse relationship between sex hormone binding globulin (SHBG) and androgenetic alopecia (AGA). Studies have shown that those with AGA have lower circulating levels of SHBG compared to the non-balding controls.

There are several drugs (like oral antiandrogens) that elevate SHBG levels but have a host of side effects that limit their usage on a continuous basis in men.

There are also, however, two health enhancing compounds that elevate SHBG levels while offering additional health benefits and are side effect free. Green Tea Extract elevates SHBG while having the added benefit of reducing estrogen levels, which via an SHBG binding route can upregulate androgen activity. Soy isoflavones have also been shown in several studies to elevate SHBG levels and to be mildly anti-estrogenic.

In addition to a significantly lower incidents of most types of cancer, including prostate cancer and breast cancer, the oriental population whose traditional diet is abundant in soy isoflavones and green tea catechins have a drastically lower overall incidence of androgenetic alopecia and acne compared to the US.

Interestingly, those of Asian origin living in the US have an almost identical incidence of androgen mediated disorders (prostate cancer, BPH, hair loss) as the US general population.


http://www.hairloss-research.org/GreenTe...sSHBG.html





Never knew that green tea and soy isoflavones increase SHBG. And never knew that soy isoflavones are slightly anti-estrogenic either. That would explain their limited success in NBE.